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N1-Azido-spermine trihydrochloride

  CAS No.: 1823475-98-4   Cat No.: BADC-01657 4.5  

N1-Azido-spermine trihydrochloride is an azide-functionalized polyamine ADC linker enabling rapid copper-free click chemistry for site-specific antibody conjugation, enhancing drug delivery precision and ADC biocompatibility.

N1-Azido-spermine trihydrochloride

Structure of 1823475-98-4

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ADC Linker
Molecular Formula
C10H27Cl3N6
Molecular Weight
337.72

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Synonyms
N1-Azido-spermine 3HCl; Spermine(HHHN3)
IUPAC Name
3-azaniumylpropyl-[4-(3-azidopropylazaniumyl)butyl]azanium;trichloride
Canonical SMILES
C(CC[NH2+]CCCN=[N+]=[N-])C[NH2+]CCC[NH3+].[Cl-].[Cl-].[Cl-]
InChI
InChI=1S/C10H24N6.3ClH/c11-5-3-8-13-6-1-2-7-14-9-4-10-15-16-12;;;/h13-14H,1-11H2;3*1H
InChIKey
OAAIMCTWMSESMM-UHFFFAOYSA-N

N1-Azido-spermine trihydrochloride is a versatile biochemical tool used in research and development across various scientific fields. Here are some key applications of N1-Azido-spermine trihydrochloride:

Chemical Biology: N1-Azido-spermine trihydrochloride is utilized in chemical biology to facilitate the study of protein interactions and modifications. By serving as a bio-orthogonal reagent, it allows researchers to label and track biomolecules in complex biological systems. This capability is essential for elucidating protein functions and interaction networks in living cells.

Drug Delivery Research: In drug delivery systems, N1-Azido-spermine trihydrochloride is employed to enhance the delivery and targeting of therapeutics. Its azido group can be used for conjugation with drugs or nanoparticles, ensuring precise delivery to targeted cells or tissues.

Material Science: N1-Azido-spermine trihydrochloride plays a role in the design and synthesis of advanced materials. It can be used to modify polymers or surfaces via click chemistry, creating functionalized materials with unique properties. These modified materials find applications in areas such as biomaterials, electronics, and nanotechnology.

Cellular Imaging: The compound is used in cellular imaging to label cells or components for visualization under a microscope. By attaching fluorescent dyes or other imaging agents through click chemistry, researchers can observe cellular processes in real-time. This application is valuable for studying cellular dynamics, pathology, and drug interactions in research settings.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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