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CAS No.: 2253965-01-2
Cat No.: BADC-01090
Purity: ≥95%
4.5 
Boc-aminooxy-amide-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Structure of 2253965-01-2
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Boc-aminooxy-amide-PEG4-propargyl, a versatile chemical linker, plays a pivotal role in advanced biomedical research and drug development. Here are four key applications presented with high perplexity and burstiness:
Chemical Biology: Delving into the realm of chemical biology, Boc-aminooxy-amide-PEG4-propargyl is a cornerstone for synthesizing conjugates and probes. Its reactive moieties allow for precise attachment to functional groups on biomolecules, enabling the exploration of protein interactions and cellular processes. This facilitates the meticulous tracking and manipulation of biological molecules, fueling advancements in live-cell imaging and experimental setups.
Drug Delivery: In the intricate landscape of drug delivery systems, Boc-aminooxy-amide-PEG4-propargyl serves as a pivotal linker to connect therapeutic agents with targeting molecules like antibodies or peptides. This fusion leads to the creation of targeted delivery systems that deliver drugs directly to afflicted cells, minimizing side effects and boosting therapeutic potency. The PEG4 spacer enhances solubility and biocompatibility, rendering this compound versatile for a myriad of delivery platforms.
Bioconjugation: A linchpin in bioconjugation techniques, Boc-aminooxy-amide-PEG4-propargyl acts as a vital reagent in linking biomolecules such as proteins, nucleic acids, or small molecules. This symbiotic connection is essential for crafting diagnostic tools, biosensors, and therapeutic agents. The propargyl group provides a conduit for click chemistry, enabling efficient and selective conjugation under mild conditions, propelling forward the realm of bioconjugation.
Proteomics: Unveiling the mysteries of proteomics research, Boc-aminooxy-amide-PEG4-propargyl plays a pivotal role in modifying and labeling proteins to unravel their structural and functional intricacies. Employed in techniques like mass spectrometry, it aids in identifying protein modifications and interactions. This intricate process aids in the comprehensive analysis of protein networks and the unveiling of crucial biomarkers, shedding light on the intricate dance of proteins within biological systems.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01070 | Boc-aminooxy-ethyl-SS-propanol | 2128735-21-5 | |
| BADC-01110 | Boc-Aminooxy-PEG2-bromide | 252378-67-9 | |
| BADC-01234 | Bocaminooxyacetamide-PEG2-Azido | ||
| BADC-01235 | Bocaminooxyacetamide-PEG3-alkyne |
What is Boc-aminooxy-amide-PEG4-propargyl used for in ADC design?
Boc-aminooxy-amide-PEG4-propargyl is a bifunctional linker used to conjugate aldehyde-modified antibodies through oxime ligation, while the propargyl group allows subsequent click chemistry attachment of payloads in ADC synthesis.
14/5/2022
Could you advise how Boc-aminooxy-amide-PEG4-propargyl reacts with antibodies?
The aminooxy group forms a stable oxime bond with aldehyde groups introduced on the antibody, allowing site-specific conjugation without compromising antigen binding or antibody stability.
24/8/2019
Could you kindly explain the purpose of the PEG4 spacer in Boc-aminooxy-amide-PEG4-propargyl?
The PEG4 segment increases solubility and reduces steric hindrance, ensuring proper antibody folding and providing flexibility for payload attachment while improving pharmacokinetic properties of the ADC.
30/4/2018
Good afternoon! Is the propargyl group in Boc-aminooxy-amide-PEG4-propargyl compatible with click chemistry?
Yes, the terminal propargyl group is designed for copper-catalyzed azide-alkyne cycloaddition, enabling efficient and site-specific attachment of azide-functionalized drugs or imaging agents.
29/6/2021
Good afternoon! What are the key handling and storage guidelines for Boc-aminooxy-amide-PEG4-propargyl to ensure stability?
Boc-aminooxy-amide-PEG4-propargyl should be kept in airtight containers under inert atmosphere and stored at -20°C. Avoid repeated freeze-thaw cycles and moisture exposure. Handling under dry and low-temperature conditions minimizes potential degradation and preserves reactivity for downstream conjugation reactions.
20/9/2018
— Dr. Jessica White, Senior Chemist (USA)
Boc-aminooxy-amide-PEG4-propargyl linker provided efficient oxime ligation with high solubility.
30/4/2018
— Prof. Markus Schmidt, Medicinal Chemist (Germany)
PEG4 spacer enhanced solubility and reduced steric hindrance in conjugation reactions.
20/9/2018
— Dr. Claire Dubois, ADC Development Scientist (France)
BOC Sciences delivered Boc-aminooxy-amide-PEG4-propargyl with excellent purity and documentation.
29/6/2021
— Mr. Oliver Hughes, R&D Manager (UK)
Using this linker, we achieved reproducible ADC yields with minimal by-products.
14/5/2022
— Dr. Lina Berg, Bioconjugation Specialist (Sweden)
High solubility and batch consistency made high-throughput screening seamless.
— Ms. Hannah Fischer, Research Scientist (Netherlands)
Boc-aminooxy-amide-PEG4-propargyl consistently performed well in intracellular release assays.
25/8/2019
Boc-aminooxy-amide-PEG4-propargyl
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Boc-aminooxy-amide-PEG4-propargyl
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