Inquiry Basket
CAS No.:
Cat No.: BADC-01285
Purity: 98.0%
4.5 
Methylcyclopropene-PEG4-NHS is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Structure of
* For research and manufacturing use only. We do not sell to patients.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
Popular Publications Citing BOC Sciences Products
Methylcyclopropene-PEG4-NHS, a versatile chemical reagent, is renowned for its ability to modify biological molecules, elevating their stability and functionality. Here are four key applications of Methylcyclopropene-PEG4-NHS:
Protein Modification: A cornerstone in protein engineering, Methylcyclopropene-PEG4-NHS is widely embraced for its prowess in attaching polyethylene glycol (PEG) moieties to proteins, a technique termed PEGylation. This transformative modification enhances protein solubility, stability, and half-life, rendering it a valuable asset in pharmaceutical realms. PEGylated proteins often exhibit mitigated immunogenicity and heightened therapeutic effectiveness, orchestrating a paradigm shift in drug development.
Drug Delivery Systems: At the forefront of innovative therapies, Methylcyclopropene-PEG4-NHS plays a pivotal role in refining drug delivery systems by optimizing the bioavailability and efficacy of therapeutic agents. Through the strategic conjugation of PEG4, drugs attain enhanced solubility and prolonged circulation within the body, culminating in amplified drug performance and targeted tissue delivery.
Biomedical Research: Serving as a catalyst in cutting-edge research endeavors, Methylcyclopropene-PEG4-NHS facilitates the exploration of intricate protein-protein interactions, offering a functional scaffold for attaching diverse biochemical probes. Researchers harness this capability to unravel the dynamics of protein networks and signaling cascades with unparalleled precision, enriching our comprehension of complex biological phenomena and disease pathogenesis.
Nanotechnology: At the nexus of scientific innovation, Methylcyclopropene-PEG4-NHS drives advancements in nanoscale carrier design for therapeutic and diagnostic applications. By leveraging PEG modification, nanoparticles acquire stealth attributes, evading immune surveillance and optimizing drug delivery mechanisms. This transformative technology amplifies the potential of nanomedicine in crafting novel treatments and cutting-edge imaging tools.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01284 | Methylcyclopropene-PEG3-amine |
What is Methylcyclopropene-PEG4-NHS and its role in ADC chemistry?
Methylcyclopropene-PEG4-NHS is a linker with an NHS ester reactive group and a methylcyclopropene moiety for bioorthogonal conjugation. It facilitates covalent attachment of antibodies and other proteins through amine-reactive chemistry.
1/7/2017
Dear team, how does Methylcyclopropene-PEG4-NHS enhance conjugation efficiency?
The NHS ester reacts rapidly with lysine residues on antibodies, while the PEG4 spacer reduces steric hindrance and improves solubility. The methylcyclopropene group allows subsequent click chemistry for payload attachment.
13/2/2022
Dear team, which types of payloads can be linked using Methylcyclopropene-PEG4-NHS?
It is suitable for payloads equipped with tetrazine or other complementary click partners, enabling efficient bioorthogonal reactions without affecting antibody stability.
14/4/2020
Good afternoon! Can Methylcyclopropene-PEG4-NHS be used in therapeutic ADC development?
Yes, it is compatible with both preclinical and therapeutic ADC development. Its stable conjugation chemistry ensures predictable pharmacokinetics and supports selective intracellular payload release.
22/8/2017
Good afternoon! How should Methylcyclopropene-PEG4-NHS be handled to prevent hydrolysis?
Methylcyclopropene-PEG4-NHS is moisture-sensitive and should be handled under anhydrous conditions. Store at -20°C in a desiccated container and minimize exposure to water or aqueous buffers to preserve reactivity for effective ADC conjugation.
27/5/2019
— Dr. Sarah Collins, Protein Chemist (USA)
Methylcyclopropene-PEG4-NHS linker enabled rapid and clean NHS ester conjugation reactions.
14/4/2020
— Prof. Markus Fischer, Medicinal Chemist (Germany)
The PEG4 spacer improved solubility and reduced steric hindrance, facilitating payload attachment.
27/5/2019
— Dr. Claudia Rossi, ADC Scientist (Italy)
BOC Sciences delivered Methylcyclopropene-PEG4-NHS with high purity and consistent quality.
22/8/2017
— Ms. Emily Parker, R&D Manager (UK)
Using this linker, we achieved reproducible conjugation with minimal side reactions.
1/7/2017
— Dr. Henrik Larsen, Bioconjugation Specialist (Denmark)
Excellent technical documentation and support accompanied Methylcyclopropene-PEG4-NHS.
— Mr. Felix Johnson, Senior Scientist (France)
The linker’s solubility and reactivity improved high-throughput ADC screening efficiency.
13/2/2022
Methylcyclopropene-PEG4-NHS
Required fields are marked with *
Methylcyclopropene-PEG4-NHS
Required fields are marked with *
Contact our experts today for pricing and comprehensive details on our ADC offerings.
From cytotoxin synthesis to linker design, discover our specialized services that complement your ADC projects.
Learn more about payload design, linker strategies, and integrated CDMO support through our curated ADC content.
Find exactly what your project needs from our expanded range of ADCs, offering flexible options to fit your timelines and goals.
