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Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01131 | -- | $-- | Inquiry |
Maleimido-tri(ethylene glycol)-propionic acid, a versatile chemical compound with a multitude of scientific and industrial uses, finds itself at the forefront of innovation in various fields.
Bioconjugation: Maleimido-tri(ethylene glycol)-propionic acid plays a pivotal role in bioconjugation techniques, serving as a bridge to connect proteins, peptides, and other biomolecules. With its maleimide group readily engaging thiol groups present in cysteine residues, stable thioether bonds are formed, allowing for the attachment of functional groups or labels. This fusion enables the customization of biomolecules for diverse applications in diagnostics, imaging, and therapeutics, showcasing the compound’s versatility in molecular assembly.
Drug Delivery Systems: Embracing cutting-edge advancements in drug delivery, this compound contributes to the development of sophisticated drug transportation systems. The tri(ethylene glycol) spacer provides enhanced solubility and flexibility, empowering the creation of drug carriers with extended circulation times and improved biodistribution. By conjugating therapeutic agents like antibodies or small molecules, targeted drug delivery is optimized, elevating treatment efficacy while minimizing adverse effects.
Surface Modification: Delving into the realm of material science, Maleimido-tri(ethylene glycol)-propionic acid emerges as a valuable asset for surface modification. By augmenting the surfaces of nanoparticles and medical devices, biocompatibility and functionalization are enhanced. The ethylene glycol units mitigate nonspecific protein binding, while the maleimide group facilitates specific biomolecule attachment, enabling tailored surface properties suitable for applications such as biosensors and implants. Unlock the potential of tailored surfaces with this compound’s distinct properties.
Protein Cross-Linking: In protein chemistry, maleimido-tri(ethylene glycol)-propionic acid takes center stage in protein cross-linking endeavors. This compound serves as a catalyst for bridging proteins, unraveling protein-protein interactions, and fortifying protein structures. Through the establishment of covalent bonds between proteins or subunit interfaces, deeper understanding of structural configurations and functional dynamics is attained.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, non-natural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
