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Fmoc-PEA

  CAS No.: 329223-23-6   Cat No.: BADC-00677 4.5  

Fmoc-PEA is a protected amino acid ADC linker intermediate used in peptide synthesis for antibody-drug conjugates. It supports selective conjugation and controlled linker assembly, enhancing ADC stability and payload attachment. Keywords: ADC linker, Fmoc protection, peptide synthesis, linker intermediate, antibody-drug conjugate.

Fmoc-PEA

Structure of 329223-23-6

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Category
ADC Linker
Molecular Formula
C17H18NO6P
Molecular Weight
363.3
Shipping
Room temperature

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
9H-fluoren-9-ylmethyl N-(2-phosphonooxyethyl)carbamate
IUPAC Name
9H-fluoren-9-ylmethyl N-(2-phosphonooxyethyl)carbamate
Canonical SMILES
O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOP(O)(O)=O
InChI
InChI=1S/C17H18NO6P/c19-17(18-9-10-24-25(20,21)22)23-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,18,19)(H2,20,21,22)
InChIKey
YHUHBHVNOVAEMP-UHFFFAOYSA-N
Shipping
Room temperature

Fmoc-PEA, a modified amino acid with diverse applications in peptide synthesis and biochemistry, boasts versatility and utility in various fields. Here are four key applications of Fmoc-PEA:

Peptide Synthesis: Serving as a fundamental building block in the intricate realm of peptide and protein synthesis, Fmoc-PEA plays a crucial role. Its Fmoc protective group facilitates the sequential addition of amino acids in solid-phase peptide synthesis (SPPS), ensuring the creation of highly pure and efficient custom peptides tailored for both research and therapeutic endeavors.

Bioconjugation: Delving into the realm of bioconjugation, Fmoc-PEA emerges as a key player in the fusion of peptides with other biomolecules, yielding bioconjugates of immense significance. This strategic linkage gives rise to a new class of molecules vital for the development of peptide-based drugs, diagnostic tools, and imaging agents. The conjugation process not only enhances the functionality and specificity of peptides but also amplifies their efficacy in diverse applications.

Structure-Activity Relationship (SAR) Studies: In the domain of SAR studies, Fmoc-PEA stands as an indispensable tool for unraveling the intricate connections between peptide structure and biological activities. By integrating Fmoc-PEA into diverse peptide sequences, researchers can discern variations in activity, binding affinity, and stability.

Protein Engineering: As a pivotal component in protein engineering, Fmoc-PEA drives innovation in the creation of novel proteins with enhanced functionalities and properties. Through its targeted incorporation into protein sequences, researchers can finely tune protein characteristics such as stability, activity, and binding interactions.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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