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Fmoc-NMe-PEG3-acid is a PEG linker containing a Fmoc-protected amine and a terminal carboxylic acid. The Fmoc group can be deprotected under the basic conditions to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01003 | -- | $-- | Inquiry |
Fmoc-NMe-PEG3-acid, a versatile chemical reagent utilized in peptide synthesis and diverse bioconjugation applications, plays a pivotal role in various scientific realms. Here are four key applications of Fmoc-NMe-PEG3-acid intricately:
Peptide Synthesis: Acting as a crucial linker in solid-phase peptide synthesis, Fmoc-NMe-PEG3-acid acts as a bridge between the peptide and resin, streamlining the synthesis and purification of intricate peptides. The incorporation of the PEG moiety not only aids in enhancing peptide solubility in aqueous solutions but also simplifies subsequent handling processes, elevating the efficiency of peptide synthesis workflows.
Drug Delivery Systems: Delving into the realm of pharmaceutical innovation, Fmoc-NMe-PEG3-acid emerges as a key player in modifying therapeutic peptides and proteins to enhance their pharmacokinetic properties. By conjugating Fmoc-NMe-PEG3-acid to drug molecules, researchers can elevate solubility, stability, and bioavailability levels, paving the way for the development of cutting-edge drug delivery systems with heightened efficacy and precision.
Bioconjugation: In bioconjugation chemistry, Fmoc-NMe-PEG3-acid assumes the role of a functional group, facilitating the linkage of biomolecules such as antibodies and enzymes to diverse surfaces or carriers. The inclusion of the PEG spacer effectively minimizes steric hindrance, preserving the bioactivity of the conjugated molecule. This method, widely embraced in diagnostics, therapeutics, and biosensors, showcases the fusion of intricate chemical processes with profound biological applications.
Proteomics Research: Stepping into the realm of proteomics, Fmoc-NMe-PEG3-acid emerges as a valuable catalyst in synthesizing peptide probes and affinity tags, essential for exploring protein-protein interactions and identifying potential drug targets. The PEG linker plays a pivotal role in preventing nonspecific interactions, paving the path for more precise and reliable outcomes in proteomics research, driving forth the frontiers of biological discovery and therapeutic innovation.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, non-natural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
