Fmoc-L-Asn(EDA-N3)-OH - CAS 2616562-74-2

Fmoc-L-Asn(EDA-N3)-OH - CAS 2616562-74-2 Catalog number: BADC-01808

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Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group.

Category
ADCs Linker
Product Name
Fmoc-L-Asn(EDA-N3)-OH
CAS
2616562-74-2
Catalog Number
BADC-01808
Molecular Formula
C21H21N5O5
Molecular Weight
423.42

Ordering Information

Catalog Number Size Price Quantity
BADC-01808 -- $-- Inquiry
Description
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group.
IUPAC Name
(2S)-4-(2-azidoethylamino)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid
Canonical SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC(=O)NCCN=[N+]=[N-])C(=O)O
InChI
InChI=1S/C21H21N5O5/c22-26-24-10-9-23-19(27)11-18(20(28)29)25-21(30)31-12-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,17-18H,9-12H2,(H,23,27)(H,25,30)(H,28,29)/t18-/m0/s1
InChIKey
MIDFHGCIXOHKEE-SFHVURJKSA-N

Fmoc-L-Asn(EDA-N3)-OH, a specialized amino acid derivative, plays a pivotal role in peptide synthesis and diverse biochemical applications. Here are four key applications of this compound:

Solid-Phase Peptide Synthesis: Serving as a fundamental component in solid-phase peptide synthesis, Fmoc-L-Asn(EDA-N3)-OH acts as a protected building block for amino acids. Its distinctive azide group (N3) allows for site-specific modifications and conjugations post-peptide assembly, particularly beneficial in the intricate design of complex peptides and proteins for both research and therapeutic endeavors.

Click Chemistry: With its distinctive azide group, Fmoc-L-Asn(EDA-N3)-OH finds relevance in click chemistry applications, enabling interactions with alkyne-containing molecules through copper-catalyzed azide-alkyne cycloaddition (CuAAC). This unique feature facilitates the precise and efficient attachment of various tags, probes, or other functional groups to peptides, advancing the exploration of protein interactions, localization, and bioconjugation processes.

Drug Development: In the realm of drug development, Fmoc-L-Asn(EDA-N3)-OH plays a crucial role in synthesizing peptide-based therapeutic candidates. By incorporating this modified amino acid, researchers can introduce novel functional groups that enhance drug properties such as stability, bioavailability, and target specificity.

Bioconjugation: This compound also holds notable value in bioconjugation initiatives, enabling the linkage of proteins or peptides to other biomolecules or surfaces. Its reactive functional groups empower the formation of conjugates with antibodies, enzymes, or nanoparticles, fostering the development of bioconjugates employed in various applications, including diagnostics, targeted drug delivery, and imaging, marking a significant stride in the realm of biotechnological advancements.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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