Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-00798 | Actinomycin D | 50-76-0 |
| Actinomycin D is a chromopeptide antineoplastic antibiotic that exhibits high antibacterial and antitumor activity. Actinomycin D binds to single- and double-stranded DNA and subsequent inhibition of RNA and protein synthesis. | Inquiry | |
| BADC-00801 | Epirubicin | 56420-45-2 |
| Epirubicin, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. It is clinically active against a broad range of tumor types, including breast cancer, malignant lymphomas, soft tissue sarcomas, lung cancer, pleural mesothelioma, gastrointestinal cancer, head and neck cancer, ovarian cancer, prostatic carcinoma, transitional bladder carcinoma and so on. | Inquiry | |
| BADC-00253 | Luteolin 7-O-glucoside | 5373-11-5 |
| Cynaroside is a flavone, a flavonoid-like chemical compound. It is a 7-O-glucoside of luteolin. | Inquiry | |
| BADC-00001 | CBT-161 | |
| CBT-161 is an ADC that STI-A0602, the monoclonal antibody targeting c-Met, links tubulin inhibitors or DNA damaging agents via C-lock. Preclinical study showed that CBT-161 significantly inhibited tumor growth. | Inquiry | |
| BADC-00328 | Topotecan | 123948-87-8 |
| Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions. It has also been used for in vitro apoptosis assays in PA317 cells. | Inquiry | |
| BADC-00330 | Irofulven | 158440-71-2 |
| Irofulven is a semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven alkylates DNA and protein macromolecules, forms adducts, and arrests cells in the S-phase of the cell cycle. | Inquiry | |
| BADC-00800 | Exatecan Mesylate | 169869-90-3 |
| Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting the religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogs. | Inquiry | |
| BADC-00266 | Galantamine hydrobromide | 1953-04-4 |
| Galantamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. It prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. | Inquiry | |
| BADC-01383 | Inebilizumab | 1299440-37-1 |
| Inebilizumab is an anti-CD19 monoclonal antibody used to treat adults with neuromyelitis optica spectrum disorders (NMOSD). | Inquiry | |
| BADC-01347 | Trastuzumab-MC-MMAE | |
| Trastuzumab-mc-MMAE is an ADC product consisting of an anti-HER2 antibody (Trastuzumab) conjugated to MMAE via an Mc linker. It has been used to treat breast, ovarian and lung cancer by depolymerizing microtubule MOA (mechanism of action). | Inquiry | |
| BADC-01362 | BAY 1135626 | 1404071-37-9 |
| BAY 1135626 is used to synthesize BAY 1129980. BAY 1129980 (C4.4A-ADC) is a promising therapeutic candidate for the treatment of NSCLC and other cancers expressing C4.4A. | Inquiry | |
| BADC-01365 | S-Me-DM4 | 890654-03-2 |
| S-Me-DM4 is an ADC cytotoxin molecule. It inhibits in vitro polymerization of tubulin and is used in the treatment of advanced breast cancer. | Inquiry | |
| BADC-01371 | 2',3'-cGAMP-C2-SH | 2133823-39-7 |
| 2',3'-cGAMP-C2-SH is an ADC Cytotoxin extracted from patent US20210015941. | Inquiry | |
| BADC-00361 | Combretastatin A4 | 117048-59-6 |
| Combretastatin A4 is a stilbenoid isolated from Combretum caffrum. Combretastatin A4 was shown to inhibit tubulin polymerization (IC50 = 2.2 μM). It has demonstrable antineoplastic activity. | Inquiry | |
| BADC-00182 | Duocarmycin analog | |
| Duocarmycin analog has cytotoxicity for solid tumor cells that can be used for antibody-drug conjugates (ADCs). Duocarmycins and the analogs acts via binding to the minor groove of DNA and alkylating the nucleobase adenine at the N3 position, which leads to DNA damage and cancer cell death. | Inquiry | |
| BADC-00791 | Illudin S | 1149-99-1 |
| Illudin S is a natural sesquiterpene agent with strong anti-tumour activity. Illudin S inhibits DNA synthesis via an unknown mechanism. | Inquiry | |
| BADC-00179 | Colcemide | 477-30-5 |
| An antineoplastic alkaloid from Colchicum autumnale L. isolated from Colchicum autumnale L. | Inquiry | |
| BADC-00346 | Maytansine | 35846-53-8 |
| Maitansine, a cytotoxic agent, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. | Inquiry | |
| BADC-01391 | Methotrexate monohydrate | 6745-93-3 |
| Methotrexate monohydrate is a DHhF reductase inhibitor that inhibits the enzyme dihydrofolate reductase and DNA synthesis. Therefore it is used to treat various cancers. | Inquiry | |
| BADC-00310 | MMAD hydrochloride | 173441-26-4 |
| Monomethyl auristatin D Hcl (MMAD Hcl), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. | Inquiry |
