Inquiry Basket
Catalog | Product Name | CAS Number |
---|---|---|
BADC-00334 | Seco-DuocarmycinDMA | |
Seco-Duocarmycin DMA is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. | Inquiry | |
BADC-00335 | DC-1 | |
DC-1 is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. | Inquiry | |
BADC-00336 | Seco-Duocamycin GA | 1613286-59-1 |
Seco-Duocarmycin GA is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. | Inquiry | |
BADC-00338 | Auristatin T | 1799603-53-4 |
A microtubule-disrupting agent. | Inquiry | |
BADC-00129 | Pentazolone hydrochloride | 21314-60-3 |
Synthetic, an inhibitor of monoamine oxydase.Enhances the toxicity of the Phenamine group and of Tryptamine. | Inquiry | |
BADC-01377 | Pyrrolobenzodiazepine (PBD) | 945490-09-5 |
Pyrrolobenzodiazepines are a class of natural products with antibiotic or anti-tumor properties. They are produced by various actinomycetes. As a class of DNA-crosslinking agents, pyrrolobenzodiazepines are significantly more potent than systemic chemotherapeutic drugs. | Inquiry | |
BADC-00792 | Illudin M | 1146-04-9 |
Illudin M is a natural sesquiterpene agent with strong anti-tumour activity. | Inquiry | |
BADC-00775 | FR-901464 | 146478-72-0 |
It is a potent cell cycle inhibitor isolated from Pseudomonas sp. No.2663. It exhibits potent antitumor activities against tumor cell lines via binding to the spliceosome and modulating pre-mRNA splicing. | Inquiry | |
BADC-01379 | Eribulin | 253128-41-5 |
Eribulin suppressed centromere dynamics at concentrations that arrest mitosis. At 60 nmol/L eribulin (2 x mitotic IC(50)), the relaxation rate was suppressed 21%, the time spent paused increased 67%, and dynamicity decreased 35% (but without reduction in mean centromere separation), indicating that eribulin decreased normal microtubule-dependent spindle tension at the kinetochores, preventing the signal for mitotic checkpoint passage. [(3)H]eribulin binds soluble tubulin at a single site; however, this binding is complex with an overall K(d) of 46 microM, but also showing a real or apparent very high affinity (K(d) = 0.4 microM) for a subset of 25% of the tubulin. Eribulin also binds microtubules with a maximum stoichiometry of 14.7 +/- 1.3 molecules per microtubule (K(d) = 3.5 microM), strongly suggesting the presence of a relatively high-affinity binding site at microtubule ends. At 100 nM, the concentration that inhibits microtubule plus end growth by 50%, we found that one molecule of eribulin is bound per two microtubules, indicating that the binding of a single eribulin molecule at a microtubule end can potently inhibit its growth. Eribulin does not suppress dynamic instability at microtubule minus ends. Eribulin's in vivo superiority derives from its ability to induce irreversible mitotic blockade, which appears related to persistent drug retention and sustained Bcl-2 phosphorylation. | Inquiry | |
BADC-00088 | Nemorubicin | 108852-90-0 |
Nemorubicin, is a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. | Inquiry | |
BADC-00569 | Cryptophycin 1 | 124689-65-2 |
Cryptophycin 1, produced by Nostoc sp. GSV 224, is a potent cytotoxic anti-microtubule agent. Cryptophycin 1 can induce cell apoptosis, and has anti-tumor activity and excellent anti-proliferation ability. | Inquiry | |
BADC-00593 | Apaziquone | 141304-51-0 |
Apaziquone is an indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Apaziquone is converted to active metabolites in hypoxic cells by intracellular reductases, which are present in greater amounts in hypoxic tumor cells. The active metabolites alkylate DNA, resulting in apoptotic cell death. | Inquiry | |
BADC-00715 | Boc-Val-Dil-Dap-OH | 1415246-54-6 |
Boc-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). | Inquiry | |
BADC-00716 | Boc-Val-Dil-Dap-Phe-OMe | |
Boc-Val-Dil-Dap-Phe-OMe is a cytotoxin for antibody-drug-conjugation (ADC). | Inquiry | |
BADC-00717 | Boc-Val-Dil-Dap-Doe | 135383-62-9 |
Boc-Val-Dil-Dap-Doe is a compound used to synthesize Dolastatin 10. Dolastatin 10 is a potent cytotoxin and involves inhibition of tubulin polymerization, tubulin-dependent guanosine triphosphate hydrolysis, and nucleotide exchange. | Inquiry | |
BADC-00718 | Boc-Val-Dil-Dap-Nrp | |
Boc-Val-Dil-Dap-Nrp is a cytotoxin for antibody-drug-conjugation (ADC). | Inquiry | |
BADC-00720 | Tubulysin IM-2 | |
Tubulysin IM-2 can be used in the synthesis of Tubulysin M. Tubulysin M is a Tubulysin D is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Tubulysin M is used as the cytotoxin in antibody-drug conjugates | Inquiry | |
BADC-00721 | Tubulysin IM-3 | |
Tubulysin IM-3 can be used in the synthesis of Tubulysin anologs. Tubulysin anologs is a class of microtubule-disrupting agents and can be used as cytotoxins in antibody-drug-conjugation (ADC). | Inquiry | |
BADC-00771 | Thailanstatin B | |
a Pre-mRNA splicing inhibitor. Thailanstatin B is used as a cytotoxin for ADCs. | Inquiry | |
BADC-00772 | Thailanstatin C | |
a Pre-mRNA splicing inhibitor. Thailanstatin C is used as a cytotoxin for ADCs. | Inquiry |