Inquiry Basket
Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate for ADC by using the antitumor antibiotic, Duocarmycin TM, linked via Fmoc-Val-Cit-PAB.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00871 | -- | $-- | Inquiry |
Fmoc-Val-Cit-PAB-Duocarmycin TM is a specialized chemical linker used in the development of targeted cancer therapies. Here are some key applications of Fmoc-Val-Cit-PAB-Duocarmycin TM:
Antibody-Drug Conjugates (ADCs): Fmoc-Val-Cit-PAB-Duocarmycin TM is used as a linker in ADCs, which are designed to deliver cytotoxic drugs specifically to cancer cells. The linker ensures that the drug remains inactive until it reaches the target cells, minimizing damage to normal tissues. This enhances the efficacy of cancer treatments while reducing systemic toxicity.
Targeted Drug Delivery: The Fmoc-Val-Cit-PAB-Duocarmycin TM linker is employed in the precise delivery of chemotherapeutic agents to tumors. By attaching cytotoxic drugs to targeting moieties, like antibodies or peptides, the linker facilitates selective drug release within the cancerous microenvironment. This targeted approach aims to maximize drug concentration at the tumor site, improving therapeutic outcomes.
Protease-Sensitive Linkers: Fmoc-Val-Cit-PAB-Duocarmycin TM utilizes a valine-citrulline dipeptide sequence that is sensitive to enzymatic cleavage by specific proteases present in the tumor microenvironment. Upon cleavage, the drug is activated and exerts its cytotoxic effects on the tumor cells. This protease-sensitive mechanism ensures that the drug is released specifically at the cancer site, minimizing off-target effects.
Drug Design and Development: Researchers use Fmoc-Val-Cit-PAB-Duocarmycin TM to study and optimize the design of new drug-linker combinations for improved cancer therapies. By investigating the stability, cleavage efficiency, and release profiles of various linker-drug constructs, scientists can develop more effective and safer ADCs. This research supports the innovation of next-generation targeted cancer treatments.
Customer Support
Providing excellent 24/7 customer service and support
Project Management
Offering 100% high-quality services at all stages
Quality Assurance
Ensuring the quality and reliability of products or services
Global Delivery
Ensuring timely delivery of products worldwide
BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
