BCN-PEG4-NHS ester is a click chemistry-enabled linker for strain-promoted azide-alkyne cycloaddition (SPAAC). Ideal for bioconjugation in ADCs without copper catalysis.
Structure of 1702356-19-1
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Size | Price | Stock | Quantity |
---|---|---|---|
50 mg | $629 | In stock |
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Capabilities & Facilities
BCN-PEG4-NHS ester, a versatile bifunctional crosslinking reagent, plays a pivotal role in bioconjugation and chemical biology. Explore its diverse applications presented with a high degree of perplexity and burstiness:
Protein Labeling: An indispensable tool for scientists, BCN-PEG4-NHS ester is harnessed for the covalent attachment of fluorescent dyes, enzymes, or other biomolecules to proteins. This strategic modification facilitates in-depth exploration of protein dynamics, localization, and interactions through cutting-edge techniques like fluorescence microscopy. The conjugation with BCN-PEG4-NHS ester not only ensures the preservation of biological activity but also enhances the solubility of the labeled proteins, opening new avenues in protein research.
Drug Delivery Systems: Enter the realm of targeted drug delivery systems empowered by BCN-PEG4-NHS ester. By conjugating drugs with specific targeting ligands, such as antibodies or peptides, using this versatile reagent, researchers orchestrate precise delivery of therapeutic agents to designated cells or tissues. This tailored approach not only amplifies the drug’s efficacy but also mitigates off-target effects.
Surface Modification: Witness the transformative power of BCN-PEG4-NHS ester in surface functionalization of nanoparticles, biomaterials, and sensors. The innate chemical groups of this reagent facilitate seamless covalent attachment of biomolecules, elevating the biocompatibility and functionality of the modified surfaces. This pivotal role is instrumental in crafting cutting-edge biosensors, medical implants, and diagnostic devices that boast enhanced performance and reliability.
Click Chemistry: Step into the realm of bio-orthogonal ‘click’ chemistry reactions, where BCN-PEG4-NHS ester shines as a key player. Its efficient reactivity with azide-functionalized molecules forms stable triazole linkages, enabling the assembly of intricate bioconjugates under mild conditions. This innovative application holds immense value in constructing multifunctional biomolecules tailored for research endeavors and therapeutic interventions, propelling scientific discovery and medical advancements to new heights.
Catalog | Product Name | CAS | Inquiry |
---|---|---|---|
BADC-01226 | BCN-PEG3-Biotin | 1263166-92-2 | |
BADC-00959 | BCN-PEG4-HyNic | 1507370-54-8 | |
BADC-01019 | BCN-PEG4-acid | 1881221-47-1 | |
BADC-01096 | BCN-PEG3-VC-PFP ester | 2353409-45-5 | |
BADC-01224 | BCN-PEG1-Val-Cit-OH | ||
BADC-01225 | BCN-PEG1-Val-Cit-PABC-OH | ||
BADC-01227 | BCN-PEG3-oxyamine | ||
BADC-01228 | BCN-PEG3-Val-Cit | ||
BADC-01229 | BCN-PEG4-OH | ||
BADC-01230 | BCN-PEG4-Ts |
What is BCN-PEG4-NHS ester and its utility in ADCs?
BCN-PEG4-NHS ester is a strained cyclooctyne linked to a PEG4-NHS ester, enabling bioorthogonal conjugation via strain-promoted azide-alkyne cycloaddition (SPAAC). It provides stable, site-specific linkage without copper catalysis.
2/2/2017
Dear BOC Sciences, how does BCN-PEG4-NHS ester facilitate site-specific ADC conjugation?
The BCN moiety reacts selectively with azide-functionalized antibodies or payloads, allowing precise control over conjugation sites and stoichiometry, which improves ADC homogeneity and therapeutic consistency.
21/2/2019
Dear BOC Sciences, which payloads are compatible with BCN-PEG4-NHS ester?
BCN-PEG4-NHS ester can conjugate azide-modified cytotoxins, fluorophores, or other functional groups, offering versatility for different ADC designs and maintaining payload activity post-conjugation.
26/9/2016
Dear team, could you please share the recommended storage conditions for BCN-PEG4-NHS ester?
BCN-PEG4-NHS ester should be stored in anhydrous solvents at low temperatures (-20°C) and protected from light to prevent hydrolysis and maintain reactivity for subsequent conjugation reactions.
5/12/2016
Dear team, how should BCN-PEG4-NHS ester be stored and handled to maintain its reactivity?
BCN-PEG4-NHS ester should be stored at -20°C in a moisture-free environment. Exposure to air or aqueous conditions should be minimized to prevent hydrolysis of the NHS ester. For laboratory use, handling under inert atmosphere and use of desiccators are recommended. Relevant analytical and safety documents are available upon request to ensure proper handling and verification.
5/10/2017
— Dr. Matthew Green, Biochemist (UK)
BCN-PEG4-NHS ester allowed efficient click chemistry conjugation in our ADC development, with excellent yield.
26/9/2016
— Ms. Anna Weber, Senior Scientist (Germany)
Batch-to-batch consistency of BCN-PEG4-NHS ester supported reproducible results in multiple ADC projects.
5/10/2017
— Prof. Hannah Lee, Bioconjugation Scientist (UK)
BCN-PEG4-NHS ester provided by BOC Sciences allowed efficient strain-promoted azide-alkyne cycloaddition. Documentation and delivery were excellent.
5/12/2016
— Prof. Hannah Lee, Bioconjugation Scientist (UK)
BCN-PEG4-NHS ester provided by BOC Sciences allowed efficient strain-promoted azide-alkyne cycloaddition. The batch quality and technical support were excellent.
2/2/2017
— Mr. Lucas Martin, Research Scientist (Canada)
BOC Sciences provided detailed QC and documentation for BCN-PEG4-NHS ester, supporting regulatory compliance.
— Dr. James Carter, Bioconjugation Scientist (USA)
BOC Sciences provided us with BCN-PEG4-NHS ester with exceptional purity and reproducibility. The technical support team was responsive and guided us through our complex conjugation experiments.
21/2/2019
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