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CAS No.: 2353409-45-5
Cat No.: BADC-01096
Purity: >98.0%
4.5 
BCN-PEG3-VC-PFP ester is a cleavable ADC linker with BCN for strain-promoted cycloaddition and Val-Cit dipeptide for enzymatic payload release, activated as PFP ester for amine coupling in ADC synthesis.
Structure of 2353409-45-5
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BCN-PEG3-VC-PFP ester, a versatile chemical reagent, plays a pivotal role in bioconjugation and drug delivery applications. Here are four key applications of BCN-PEG3-VC-PFP ester presented with high perplexity and burstiness：
Drug Delivery Systems: In the realm of drug delivery, BCN-PEG3-VC-PFP ester serves as a cornerstone in crafting targeted delivery systems. By conjugating drugs with polyethylene glycol (PEG), the ester elevates drug solubility, stability, and half-life in the circulation. This augmentation enhances therapeutic agent efficacy while mitigating adverse effects, marking a paradigm shift in drug delivery precision.
Proteomics: Embarking on a journey through proteomics, BCN-PEG3-VC-PFP ester emerges as a critical tool for protein labeling and crosslinking. The PEG3 spacer, with its inherent flexibility, bridges and spaces linked proteins, facilitating intricate protein interaction investigations.
Biomaterials: Venturing into biomaterial modification, BCN-PEG3-VC-PFP ester plays a pivotal role in enhancing biocompatibility and functionality. By grafting PEG onto surfaces such as medical implants or tissue engineering scaffolds, the ester enhances hydrophilicity and reduces nonspecific protein binding. This transformative process fuels the development of next-generation biomaterials with bespoke properties tailored for diverse medical applications.
Chemical Biology: Diving into the depths of chemical biology, the BCN-PEG3-VC-PFP ester emerges as a catalyst for creating clickable bioconjugates through strain-promoted alkyne-azide cycloaddition (SPAAC). This bioorthogonal reaction paves the way for labeling biomolecules in live cells without disrupting native biochemical processes.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01226 | BCN-PEG3-Biotin | 1263166-92-2 | |
| BADC-00959 | BCN-PEG4-HyNic | 1507370-54-8 | |
| BADC-00415 | BCN-PEG4-NHS ester | 1702356-19-1 | |
| BADC-01019 | BCN-PEG4-acid | 1881221-47-1 | |
| BADC-01224 | BCN-PEG1-Val-Cit-OH | ||
| BADC-01225 | BCN-PEG1-Val-Cit-PABC-OH | ||
| BADC-01227 | BCN-PEG3-oxyamine | ||
| BADC-01228 | BCN-PEG3-Val-Cit | ||
| BADC-01229 | BCN-PEG4-OH | ||
| BADC-01230 | BCN-PEG4-Ts |
BCN-PEG3-VC-PFP ester
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BCN-PEG3-VC-PFP ester
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