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BCN-PEG3-Biotin

  CAS No.: 1263166-92-2   Cat No.: BADC-01226   Purity: 98.0% 4.5  

BCN-PEG3-Biotin combines strain-promoted click chemistry and biotin affinity in a PEGylated ADC linker. Facilitates efficient antibody conjugation and targeted payload delivery in ADC development.

BCN-PEG3-Biotin

Structure of 1263166-92-2

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Category
ADC Linker
Molecular Formula
C29H46N4O7S
Molecular Weight
594.76
Shipping
-20°C (International: -20°C)
Shipping
Store at -20 °C, keep in dry and avoid sunlight.

* For research and manufacturing use only. We do not sell to patients.

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Capabilities & Facilities

Popular Publications Citing BOC Sciences Products
Synonyms
endo-BCN-PEG3-Biotin
IUPAC Name
[(1S,8R)-9-bicyclo[6.1.0]non-4-ynyl]methyl N-[2-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethyl]carbamate
Canonical SMILES
C1CC2C(C2COC(=O)NCCOCCOCCOCCNC(=O)CCCCC3C4C(CS3)NC(=O)N4)CCC#C1
InChI
InChI=1S/C29H46N4O7S/c34-26(10-6-5-9-25-27-24(20-41-25)32-28(35)33-27)30-11-13-37-15-17-39-18-16-38-14-12-31-29(36)40-19-23-21-7-3-1-2-4-8-22(21)23/h21-25,27H,3-20H2,(H,30,34)(H,31,36)(H2,32,33,35)/t21-,22+,23?,24-,25-,27-/m0/s1
InChIKey
LZIHJLCCQAFQSO-MSBMMZNKSA-N
Density
1.25±0.1 g/cm3
Solubility
10 mm in DMSO
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
-20°C (International: -20°C)
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Boiling Point
847.5±65.0 °C at 760 mmHg

BCN-PEG3-Biotin, a versatile bifunctional reagent widely employed in bioconjugation, finds diverse applications across scientific disciplines. Here are four key applications of BCN-PEG3-Biotin, presented with high perplexity and burstiness:

Protein Labeling: Embracing BCN-PEG3-Biotin for protein labeling opens avenues for studying intricate protein interactions and functions. By biotinylating specific proteins, researchers can harness streptavidin-based assays and purification methods. This approach empowers the exploration of protein dynamics within cellular processes and facilitates the discovery of protein partners through meticulous experimentation.

Targeted Drug Delivery: BCN-PEG3-Biotin emerges as a pivotal player in the realm of targeted drug delivery systems. It enables the precise direction of biotinylated drugs towards biotin-binding proteins or receptors on cell surfaces. This targeted approach enhances treatment efficacy by ensuring drugs reach their designated targets, thus minimizing off-target effects and toxicity.

Cell Surface Modification: Leveraging BCN-PEG3-Biotin for cell surface modification, researchers can introduce biotin groups for probing with streptavidin-conjugated molecules. This technique proves invaluable for applications like cell sorting, imaging, and tracking cell populations across research settings. By enabling selective binding to modified cells, scientists can delve into the functions and interactions of cell surface proteins with heightened accuracy and granularity.

Bioconjugation for Assay Development: BCN-PEG3-Biotin serves as a cornerstone for bioconjugation in assay development, allowing the conjugation of enzymes, antibodies, and other biomolecules to enhance assay sensitivity and specificity. This bioconjugation prowess elevates the precision of diverse bioassays such as ELISA or immunoprecipitation. Researchers can meticulously capture and detect target molecules, thereby refining the accuracy and reliability of experimental outcomes.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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