Name: Fmoc-NH-ethyl-SS-propionic NHS ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Synonyms

2,5-dioxopyrrolidin-1-yl 3-((2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)disulfanyl)propanoate

IUPAC Name

Canonical SMILES

C1CC(=O)N(C1=O)OC(=O)CCSSCCNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

InChI

InChI=1S/C24H24N2O6S2/c27-21-9-10-22(28)26(21)32-23(29)11-13-33-34-14-12-25-24(30)31-15-20-18-7-3-1-5-16(18)17-6-2-4-8-19(17)20/h1-8,20H,9-15H2,(H,25,30)

InChIKey

XTOJUNPXMJPADI-UHFFFAOYSA-N

Solubility

10 mm in DMSO

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature, or blue ice upon request.

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Fmoc-NH-ethyl-SS-propionic NHS ester, a versatile reagent in peptide synthesis and conjugation chemistry, finds wide-ranging applications. Here are four key uses:

Peptide Synthesis: Playing a pivotal role in solid-phase peptide synthesis, Fmoc-NH-ethyl-SS-propionic NHS ester is crucial for safeguarding and activating amino groups. This compound ensures the stable attachment of amino acids while mitigating undesired side reactions. Its gentle cleavage conditions preserve the integrity of the synthesized peptide, allowing for the precise construction of peptide sequences with high efficiency.

Protein Conjugation: In the realm of protein modification, this NHS ester emerges as a versatile tool for conjugating proteins with diverse functional groups, including fluorescent dyes, drugs, or other biomolecules. Through its reaction with primary amines on proteins, it forms robust amide bonds, facilitating the generation of bioconjugates for applications spanning imaging, diagnostics, and targeted therapies.

Surface Modification: Stepping into the domain of surface functionalization, Fmoc-NH-ethyl-SS-propionic NHS ester acts as a potent agent for attaching bioactive molecules to surfaces. By binding to amine groups on substrates, this reagent enables the modification of surfaces with peptides, antibodies, or polymers. This application holds substantial value for crafting biosensors, biomaterials, and tissue engineering scaffolds, offering a versatile platform for tailored surface engineering solutions.

Nucleic Acid Labeling: Transitioning to nucleic acid labeling, this compound proves instrumental in labeling nucleic acids by binding to amino-modified oligonucleotides or nucleotides. The resultant labeled nucleic acids find diverse applications in molecular biology, including hybridization assays, sequencing, and fluorescence-based detection methods. This labeling strategy enhances the sensitivity and specificity of nucleic acid-based techniques, empowering researchers with powerful tools for molecular analysis and manipulation.