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2, 5-Dioxopyrrolidin-1-yl 3-((3-((3-(trityloxy)propanoyl)oxy)propanoyl)oxy)propanoate is a linker for antibody-drug-conjugation (ADC).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00599 | -- | $-- | Inquiry |
2,5-Dioxopyrrolidin-1-yl 3-((3-((3-(trityloxy)propanoyl)oxy)propanoyl)oxy)propanoate is widely utilized in chemical synthesis as a coupling reagent. Its structure allows it to facilitate the formation of esters and amides, which are crucial in the development of complex organic molecules. This reagent is particularly effective in solid-phase peptide synthesis, enabling the formation of peptide bonds with high efficiency and minimal side reactions. The presence of the trityl group enhances its stability and reactiveness, making it a preferred choice for synthesizing long-chain peptides and proteins in biomedical research.
Another significant application of 2,5-Dioxopyrrolidin-1-yl 3-((3-((3-(trityloxy)propanoyl)oxy)propanoyl)oxy)propanoate is its use in pharmaceutical conjugation processes. The compound can be employed to attach drug molecules to carrier proteins or other delivery systems, enhancing the therapeutic efficacy and targeting of the drug. This property is especially valuable in the development of antibody-drug conjugates (ADCs), where it helps in the precise conjugation of cytotoxic drugs to antibodies, ensuring that the cytotoxic effect is targeted solely to cancer cells, thereby reducing systemic toxicity and improving patient outcomes.
In the field of materials science, 2,5-Dioxopyrrolidin-1-yl 3-((3-((3-(trityloxy)propanoyl)oxy)propanoyl)oxy)propanoate is used in the modification of polymer surfaces. Its ability to introduce functional groups onto polymer substrates facilitates the development of advanced materials with tailored properties. For instance, it can be used to graft bioactive molecules, such as proteins and enzymes, onto biodegradable polymers to create biomaterials for tissue engineering and regenerative medicine. This functionalization enhances the interaction between cells and the material, promoting cell adhesion, growth, and differentiation.
Moreover, 2,5-Dioxopyrrolidin-1-yl 3-((3-((3-(trityloxy)propanoyl)oxy)propanoyl)oxy)propanoate is employed in the synthesis of dendrimers and other branching molecules. Dendrimers are highly branched, tree-like structures that have applications in drug delivery, diagnostics, and nanotechnology. The compound’s ability to form stable linkages with various functional groups makes it ideal for constructing these complex molecular architectures. By facilitating the stepwise addition of monomer units, it allows for the precise control over the size and functionality of the dendrimers, making them suitable for encapsulating drugs, imaging agents, and other therapeutic molecules.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
