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H-D-Lys(N3)-OH - CAS 1418009-93-4

H-D-Lys(N3)-OH - CAS 1418009-93-4 Catalog number: BADC-01968

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H-D-Lys(N3)-OH is a modified amino acid with an azide group on the ε-amino group of lysine. The azide group enables bioorthogonal reactions, particularly in click chemistry, allowing the attachment of various functional groups to peptides and proteins. This makes it a valuable tool in bioconjugation and peptide synthesis, used for labeling proteins and studying their interactions and dynamics within cells.

Category
ADC Linker
Product Name
H-D-Lys(N3)-OH
CAS
1418009-93-4
Catalog Number
BADC-01968
Molecular Formula
C6H12N4O2
Molecular Weight
172.19
Purity
≥99% by HPLC
H-D-Lys(N3)-OH

Ordering Information

Catalog Number Size Price Quantity
BADC-01968 -- $-- Inquiry
Synonyms
6-Azido-D-norleucine; D-Azidonorleucine; H-D-Nle(6-N3)-OH; (R)-6-Azido-2-amino-hexanoic; D-Azidolysine; D-Anl; H-D-Lys(N3); H-D-Nle(N3)-OH; 6-Azido-D-lysine; N6-Diazo-D-lysine; (R)-2-Amino-6-azidohexanoic acid; N-epsilon-Azido-D-lysine; N-epsilon-Azido-D-norleucine; Nε-Azido-D-Lysine
IUPAC Name
(2R)-2-amino-6-azidohexanoic acid
Canonical SMILES
C(CCN=[N+]=[N-])C[C@H](C(=O)O)N
InChI
InChI=1S/C6H12N4O2/c7-5(6(11)12)3-1-2-4-9-10-8/h5H,1-4,7H2,(H,11,12)/t5-/m1/s1
InChIKey
HTFFMYRVHHNNBE-RXMQYKEDSA-N
Melting Point
166-172 °C
Appearance
White crystalline powder
Storage
Store at 2-8 °C
Related CAS
2098497-01-7 (monohydrochloride)
1. 1-Haloacylpiperazines
S Groszkowski, J Sienkiewicz, L Korzycka Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):183-6.
By direct acylation of piperazine with halogenocarboxylic acid chlorides in acid medium, the hydrochlorides of 1-haloacylpiperazines were obtained.
2. Metal-free and regiospecific synthesis of 3-arylindoles
Chuangchuang Xu, Wenlai Xie, Jiaxi Xu Org Biomol Chem. 2020 Apr 8;18(14):2661-2671. doi: 10.1039/d0ob00317d.
A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ring-opening reaction of aryloxiranecarbonitriles and arylhydrazine hydrochlorides and Fischer indolization. The organic base triethylamine plays a crucial role in the final elimination step in the Fischer indole synthesis, affording 3-arylindoles regiospecifically. The reaction features advantages of microwave acceleration, non-metal participation, short reaction time, organic acid-base co-catalysis, and broad substrate scope.
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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