Name: (S,E)-TCO2-PEG4-NHS ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

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IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[[(1S,2E)-cyclooct-2-en-1-yl]oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Canonical SMILES

C1CCC=CC(CC1)OC(=O)NCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O

InChI

InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h4,6,20H,1-3,5,7-19H2,(H,25,30)/b6-4+/t20-/m1/s1

InChIKey

VIRDRNWTHXGGOW-PEAOBZDDSA-N

(S,E)-TCO2-PEG4-NHS ester, a versatile chemical linker utilized in diverse bioscience applications, plays a pivotal role in various key applications characterized by high perplexity and burstiness.

Bioconjugation: (S,E)-TCO2-PEG4-NHS ester serves as a fundamental tool in bioconjugation, facilitating the linkage of biomolecules like proteins, peptides, and antibodies through the formation of stable amide bonds with primary amines. This intricate process enables targeted delivery and enhanced solubility of therapeutic molecules, essential for advancing antibody-drug conjugates and diagnostic assays towards groundbreaking discoveries.

Drug Delivery: The incorporation of the hydrophilic PEG segment in (S,E)-TCO2-PEG4-NHS ester elevates the solubility and biocompatibility of drug molecules, making it a preferred choice for modifying drug carriers such as liposomes and nanoparticles. This enhancement optimizes circulation time and diminishes immunogenicity, resulting in more effective and precise drug delivery mechanisms with profound implications for medical advancements.

Surface Modification: Leveraging (S,E)-TCO2-PEG4-NHS ester for surface modification of medical devices and biosensors introduces antifouling properties and diminishes non-specific binding, crucial for enhancing device performance and durability. By creating a hydrophilic barrier through PEG chain attachment, the linker resists protein adsorption and cell adhesion, thus revolutionizing the landscape of implants and diagnostic devices with a focus on longevity and efficacy.

Proteomics and Protein Labeling: In the realm of proteomic studies, (S,E)-TCO2-PEG4-NHS ester emerges as a pivotal component for protein labeling, enabling researchers to identify and quantify proteins with precision. Through covalent attachment of fluorescent dyes or affinity tags, scientists gain insights into protein interactions, post-translational modifications, and expression levels, thereby unlocking high-throughput screening capabilities and deepening the comprehension of intricate biological systems.