Name: (S,E)-TCO2-PEG8-NHS ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

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IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[[(1S,2E)-cyclooct-2-en-1-yl]oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Canonical SMILES

C1CCC=CC(CC1)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O

InChI

InChI=1S/C32H54N2O14/c35-29-8-9-30(36)34(29)48-31(37)10-12-39-14-16-41-18-20-43-22-24-45-26-27-46-25-23-44-21-19-42-17-15-40-13-11-33-32(38)47-28-6-4-2-1-3-5-7-28/h4,6,28H,1-3,5,7-27H2,(H,33,38)/b6-4+/t28-/m1/s1

InChIKey

MZIQTDNEOIBQJT-ZPUKQLKQSA-N

(S,E)-TCO2-PEG8-NHS ester is a specialized reagent used in the field of bioconjugation and drug delivery research. Here are some key applications of (S,E)-TCO2-PEG8-NHS ester:

Protein Labeling: (S,E)-TCO2-PEG8-NHS ester is used to covalently attach polyethylene glycol (PEG) molecules to proteins. This process, known as PEGylation, can improve the solubility, stability, and circulation half-life of therapeutic proteins. The biocompatible nature of PEG helps reduce immunogenicity and enhances the therapeutic efficacy of protein-based drugs.

Antibody-Drug Conjugates: In the development of antibody-drug conjugates (ADCs), (S,E)-TCO2-PEG8-NHS ester can be used to conjugate cytotoxic drugs to antibodies. This conjugation improves the selective delivery of drugs to target cancer cells, minimizing side effects on healthy tissues. The PEG linker enhances the stability and bioavailability of the ADCs, making them more effective in cancer therapy.

Surface Modification: (S,E)-TCO2-PEG8-NHS ester is effective in modifying the surfaces of biomaterials and nanoparticles to enhance their biocompatibility and functionalization. By attaching PEG chains to these surfaces, researchers can reduce nonspecific protein adsorption and improve the stability of the materials in biological environments. This is essential for applications in biosensors, drug delivery systems, and tissue engineering.

Cellular Imaging: The ester group in (S,E)-TCO2-PEG8-NHS ester allows for the conjugation of fluorescent dyes or imaging agents to biomolecules, facilitating cellular imaging studies. By labeling proteins or antibodies with fluorescent PEG derivatives, researchers can track and visualize cellular processes in real-time. This is crucial for studying protein localization, cell signaling, and other dynamic cellular activities.