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| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01260 | -- | $-- | Inquiry |
Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a peptide-based linker commonly used in the synthesis of antibody-drug conjugates (ADCs) and other drug delivery systems. Here are some key applications of Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP:
Antibody-Drug Conjugates (ADCs): Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is frequently employed in the development of ADCs to link cytotoxic drugs to antibodies. This linker is cleavable in the tumor microenvironment, ensuring the release of the drug specifically at the cancer site. It contributes to the targeted delivery of chemotherapeutic agents, enhancing their efficacy while reducing systemic toxicity.
Targeted Drug Delivery: Beyond ADCs, this linker is useful in a variety of targeted drug delivery systems. By coupling therapeutic agents to targeting moieties like peptides or small molecules, Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP facilitates the delivery of drugs to specific tissues or cell types. This approach improves the therapeutic index and minimizes off-target effects.
Protease-Sensitive Linkers: The Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP linker is designed to be sensitive to proteases found in certain biological environments. This property allows for controlled drug release upon encountering specific enzymatic activity. It is particularly beneficial for drugs intended to act in protease-rich environments like tumors or inflamed tissues.
Bioconjugation Research: Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is used in bioconjugation studies to explore new drug delivery mechanisms and linker designs. Researchers can use this linker to systematically study the impact of linker cleavage rates, stability, and drug release profiles on therapeutic outcomes. These studies aid in optimizing the design of next-generation drug delivery systems.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
