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CAS No.:
Cat No.: BADC-01260
Purity: 98.0%
4.5 
Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a peptide-based cleavable ADC linker with multiple protective groups, optimized for targeted payload release and precise antibody conjugation in ADC development.
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Popular Publications Citing BOC Sciences Products
Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a peptide-based linker commonly used in the synthesis of antibody-drug conjugates (ADCs) and other drug delivery systems. Here are some key applications of Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP:
Antibody-Drug Conjugates (ADCs): Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is frequently employed in the development of ADCs to link cytotoxic drugs to antibodies. This linker is cleavable in the tumor microenvironment, ensuring the release of the drug specifically at the cancer site. It contributes to the targeted delivery of chemotherapeutic agents, enhancing their efficacy while reducing systemic toxicity.
Targeted Drug Delivery: Beyond ADCs, this linker is useful in a variety of targeted drug delivery systems. By coupling therapeutic agents to targeting moieties like peptides or small molecules, Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP facilitates the delivery of drugs to specific tissues or cell types. This approach improves the therapeutic index and minimizes off-target effects.
Protease-Sensitive Linkers: The Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP linker is designed to be sensitive to proteases found in certain biological environments. This property allows for controlled drug release upon encountering specific enzymatic activity. It is particularly beneficial for drugs intended to act in protease-rich environments like tumors or inflamed tissues.
Bioconjugation Research: Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is used in bioconjugation studies to explore new drug delivery mechanisms and linker designs. Researchers can use this linker to systematically study the impact of linker cleavage rates, stability, and drug release profiles on therapeutic outcomes. These studies aid in optimizing the design of next-generation drug delivery systems.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01679 | Mal-PEG2-Val-Cit-PABA-PNP | 1345681-52-8 | |
| BADC-00929 | Fmoc-D-Val-Cit-PAB | 1350456-65-3 | |
| BADC-00849 | Acetylene-linker-Val-Cit-PABC-MMAE | 1411977-95-1 | |
| BADC-01448 | mDPR-Val-Cit-PAB-MMAE | 1491152-26-1 | |
| BADC-00958 | Amino-PEG4-Val-Cit-PAB-MMAE | 1492056-71-9 | |
| BADC-00708 | Val-cit-PAB-OH | 159857-79-1 | |
| BADC-00968 | MC-Val-Cit-PAB | 159857-80-4 | |
| BADC-00364 | Fmoc-Val-Cit-PAB | 159858-22-7 | |
| BADC-01348 | Val-Cit-PAB-MMAE TFA salt | 1608127-32-7 | |
| BADC-01745 | MC-Val-Cit-PAB-NH-C2-NH-Boc | 1616727-22-0 |
What is Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP used for in ADC synthesis?
Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a protected peptide-based linker utilized in ADC synthesis to enable stepwise assembly and attachment of payloads while maintaining control over conjugation chemistry.
14/12/2018
Could you explain how Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP improves conjugation efficiency?
The Fmoc and Boc protecting groups provide temporary steric protection, allowing selective activation of reactive sites and facilitating precise payload conjugation under controlled conditions.
19/10/2017
We are interested in which payloads are suitable for conjugation with Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP.
It is compatible with payloads containing primary amines or hydroxyl groups, enabling efficient coupling through the PAB-PNP functional group while preserving antibody stability.
12/8/2021
Good afternoon! What precautions should be taken when handling Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP?
Precautions include maintaining anhydrous reaction conditions, protecting from light and moisture, and careful monitoring of deprotection steps to prevent premature cleavage or side reactions.
29/9/2020
Dear BOC Sciences, what handling and storage practices do you recommend for Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP?
Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP should be stored at -20°C in a desiccated environment, protected from light and moisture. Minimizing exposure preserves the Fmoc, Boc, and PNP ester groups. Aliquoting is advised for repeated use, maintaining consistent reactivity for peptide synthesis and ADC conjugation.
10/10/2017
— Dr. Sarah Collins, Protein Chemist (USA)
Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP peptide linker showed excellent solubility and high reactivity for conjugation.
12/8/2021
— Prof. Markus Fischer, Medicinal Chemist (Germany)
The linker’s PEGylated structure reduced steric hindrance and improved payload accessibility.
10/10/2017
— Dr. Claudia Rossi, ADC Scientist (Italy)
BOC Sciences delivered Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP with high purity and batch consistency.
29/9/2020
— Ms. Emily Parker, R&D Manager (UK)
Smooth aqueous conjugations and minimal aggregation were observed using this linker.
14/12/2018
— Dr. Henrik Larsen, Bioconjugation Specialist (Denmark)
The peptide linker enhanced conjugation yield and workflow efficiency. Very satisfied.
— Mr. Felix Johnson, Senior Scientist (France)
High-quality linker that simplified ADC development. Excellent support from BOC Sciences.
19/10/2017
Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP
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Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP
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