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Desthiobiotin-Iodoacetamide can be used as an ADC linker.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01861 | -- | $-- | Inquiry |
Desthiobiotin-Iodoacetamide, a versatile chemical reagent in biochemistry and molecular biology, finds diverse applications. Here are four key applications:
Protein Labeling: A cornerstone in protein research, Desthiobiotin-Iodoacetamide is renowned for its selective labeling of cysteine residues within proteins. Through the covalent binding of its iodoacetamide group to cysteine residues, it enables the subsequent identification and extraction of these modified proteins using biotin-streptavidin systems. This methodology is fundamental for delving into protein-protein interactions, post-translational modifications, and the intricate functions of proteins.
Affinity Purification: The incorporation of a biotin moiety elevates Desthiobiotin-Iodoacetamide as a favored tool for affinity purification procedures. Upon labeling proteins, they can be effortlessly purified using streptavidin-coated beads or columns, ensuring a meticulous extraction of the protein of interest from complex mixtures with unparalleled purity and specificity.
Proteomics: Within the realm of proteomics, Desthiobiotin-Iodoacetamide emerges as an indispensable asset for the identification and quantification of cysteine-containing peptides. In mass spectrometry endeavors, it plays a pivotal role in the enrichment and scrutiny of peptides, yielding comprehensive insights into the protein’s architecture and functionality. This aspect is imperative for unraveling the intricacies of the proteome landscape and unearthing novel biomarkers that fuel advancements in biological sciences.
Cell Surface Labeling: An intriguing facet of Desthiobiotin-Iodoacetamide lies in its utility for labeling cell surface proteins, particularly in tracking the dynamics and interactions of membrane proteins through the tagging of cell surface cysteine residues. This application is instrumental in dissecting cell signaling pathways, unraveling receptor-ligand interactions, and deciphering cellular responses to external stimuli, shedding light on the complex interplay within cellular systems.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
