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Biotin-TEG-ATFBA

  CAS No.: 1264662-85-2   Cat No.: BADC-01707 4.5  

Biotin-TEG-ATFBA is a multifunctional ADC linker featuring biotin and TEG spacer for enhanced solubility and targeting in antibody-drug conjugates. It enables efficient payload conjugation through biotin-streptavidin affinity, ideal for targeted drug delivery and bioconjugation applications. Keywords: ADC linker, biotin linker, TEG spacer, targeted therapy, payload attachment.

Biotin-TEG-ATFBA

Structure of 1264662-85-2

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ADC Linker
Molecular Formula
C27H37F4N7O6S
Molecular Weight
663.68

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
Biotin-triethylenglycol-(p-azido-tetrafluorobenzamide); Biotin-PEG3-TFPA
IUPAC Name
4-azido-2,3,5,6-tetrafluoro-N-[3-[2-[2-[3-[5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanoylamino]propoxy]ethoxy]ethoxy]propyl]benzamide
Canonical SMILES
C1C2C(C(S1)CCCCC(=O)NCCCOCCOCCOCCCNC(=O)C3=C(C(=C(C(=C3F)F)N=[N+]=[N-])F)F)NC(=O)N2
InChI
InChI=1S/C27H37F4N7O6S/c28-20-19(21(29)23(31)25(22(20)30)37-38-32)26(40)34-8-4-10-43-12-14-44-13-11-42-9-3-7-33-18(39)6-2-1-5-17-24-16(15-45-17)35-27(41)36-24/h16-17,24H,1-15H2,(H,33,39)(H,34,40)(H2,35,36,41)
InChIKey
GHQODKUWTHCHCF-UHFFFAOYSA-N

Biotin-TEG-ATFBA, a specialized bioconjugate tailored for targeted applications in bioscience, exhibits a remarkable range of uses. Here are four key applications presented with high perplexity and burstiness:

Affinity Purification: Employing Biotin-TEG-ATFBA in affinity purification techniques allows researchers to isolate specific proteins, nucleic acids, or cellular components with precision. By linking Biotin-TEG-ATFBA to a target molecule, scientists can capture and purify the target utilizing streptavidin-coated beads. This methodology guarantees unparalleled specificity and efficiency in the purification process, facilitating in-depth analyses of the target molecules.

Biological Imaging: The versatile Biotin-TEG-ATFBA finds applications in biological imaging, where it serves to label and visualize specific biomolecules under microscopic scrutiny. By attaching this bioconjugate to antibodies or other targeting molecules, researchers can employ fluorescent or electron microscopy to observe the distribution and localization of targets within cells or tissues. This aids in comprehending the spatial organization and dynamics of intricate biological systems.

Diagnostic Assays: Biotin-TEG-ATFBA plays a pivotal role in enhancing the sensitivity and specificity of diagnostic assays. When conjugated to detection antibodies or probes, it facilitates easy capture and signal amplification through biotin-streptavidin interactions. This augmentation significantly boosts the performance of assays like ELISA, Lateral Flow Assays, and Western Blotting, enabling superior detection and quantification of vital biomarkers.

Drug Delivery Research: In the realm of drug delivery research, Biotin-TEG-ATFBA emerges as a valuable tool for targeting specific cells or tissues with precision. By conjugating it to drugs or nanoparticles, researchers leverage biotin-streptavidin interactions to deliver therapeutic agents directly to the intended sites. This targeted approach not only enhances treatment efficacy but also minimizes off-target effects, laying the groundwork for the advancement of personalized medicine.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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