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CAS No.:
Cat No.: BADC-00756
4.5 
DBCO-PEG4-vc-PAB-MMAF is a drug-linker conjugate for ADC by using Monomethylauristatin F (MMAF, a potent tubulin polymerization inhibitor), linked via DBCO-PEG4-vc-PAB.
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| Size | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $3148 | In stock |
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DBCO-PEG4-vc-PAB-MMAF is a chemically synthesized linker-drug conjugate used in targeted cancer therapy and biochemical research. Here are some key applications of DBCO-PEG4-vc-PAB-MMAF:
Antibody-Drug Conjugates (ADCs): DBCO-PEG4-vc-PAB-MMAF is widely used in the development of ADCs for targeted cancer therapy. The DBCO moiety allows for the conjugation to antibodies that selectively target cancer cells, while the MMAF component, a potent cytotoxin, is released inside targeted cells to induce apoptosis. This method enhances the therapeutic efficacy while minimizing damage to healthy cells, providing a more focused treatment approach.
Cell Line Engineering: This compound is employed in cell line engineering to study cancer cell biology and drug responses. Researchers use it to selectively kill cancer cells expressing specific markers, enabling the creation of cell lines with desired genetic traits. This application helps in understanding cancer mechanisms and testing new therapeutic strategies in a controlled environment.
In Vivo Imaging and Pharmacokinetics: DBCO-PEG4-vc-PAB-MMAF can be used in preclinical studies to evaluate the in vivo distribution and pharmacokinetics of ADCs. By tagging the linker-drug conjugate with imaging agents, researchers can visualize and track its biodistribution in animal models of cancer. This provides valuable information on the compound’s stability, efficacy, and potential off-target effects.
Biosensor Development: The DBCO moiety in DBCO-PEG4-vc-PAB-MMAF is used for click chemistry, a bio-orthogonal reaction that enables the rapid and specific conjugation of biomolecules. This property is exploited in the development of biosensors for detecting and quantifying biomolecules in complex mixtures. Such biosensors have applications in diagnostics, clinical research, and environmental monitoring.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01432 | Cys-MC-MMAF | 1160590-05-5 | |
| BADC-00592 | MC-Alkyl-Hydrazine Modified MMAF | 1404071-64-2 | |
| BADC-01455 | Modified MMAF-C5-COOH | 1404071-65-3 | |
| BADC-00594 | PEG4-aminooxy-MMAF | 1415246-35-3 | |
| BADC-00617 | MMAF sodium | 1799706-65-2 | |
| BADC-01460 | DBM-MMAF | 1810001-93-4 | |
| BADC-00863 | DBCO-PEG4-Val-Cit-PAB-MMAF | 2244602-23-9 | |
| BADC-00751 | DBCO-PEG4-MMAF | 2360411-65-8 | |
| 2413724-69-1 | (R)-N-((S)-(2-(Di(adamantan-1-yl)phosphino)phenyl)(phenyl)methyl)-N,2-dimethylpropane-2-sulfinamide | 2413724-69-1 | |
| 389868-12-6 | Ac-Glu-Glu-Val-Val-Ala-Cys-pNA | 389868-12-6 |
What is the primary application of DBCO-PEG4-vc-PAB-MMAF?
DBCO-PEG4-vc-PAB-MMAF is a click chemistry-compatible drug-linker conjugate used in the synthesis of ADCs. Its primary application is to provide a pre-activated, "ready-to-conjugate" component that can be efficiently attached to an azide-modified antibody via a copper-free click reaction. This simplifies the bioconjugation process.
10/5/2022
We are interested in how the DBCO group facilitates conjugation.
The DBCO (dibenzocyclooctyne) group enables copper-free click chemistry. This strain-promoted alkyne-azide cycloaddition (SPAAC) reaction allows for the conjugation of the drug-linker to an azide-modified antibody under mild, biocompatible conditions. This method avoids the use of cytotoxic copper catalysts, which is a significant advantage in bioconjugation.
11/9/2021
Dear team, could you explain the function of the PEG4 spacer in the structure?
The PEG4 spacer serves to increase the solubility and stability of the drug-linker conjugate. By adding a short polyethylene glycol chain, it reduces the hydrophobicity of the compound, which can mitigate aggregation. This improved solubility is crucial for maintaining the integrity and yield of the final ADC product.
2/4/2018
Could you please clarify what role the vc-PAB components play?
The vc-PAB components constitute a well-established cleavable linker system. The Val-Cit (vc) dipeptide is a substrate for the lysosomal protease cathepsin B, while the PAB (p-aminobenzyl) self-immolative spacer ensures the release of the MMAF payload. This mechanism guarantees that the payload is liberated only after the ADC has been internalized by the target cell.
26/6/2019
Good morning! How does this conjugate improve the ADC manufacturing process?
DBCO-PEG4-vc-PAB-MMAF streamlines ADC manufacturing by offering a highly efficient and bioorthogonal conjugation method. The click chemistry approach provides site-specific conjugation, leading to more homogeneous ADCs with a controlled drug-to-antibody ratio. This precision and simplicity are vital for producing consistent and high-quality biotherapeutics.
7/8/2022
— Dr. Richard Evans, Senior Scientist (USA)
DBCO-PEG4-vc-PAB-MMAF purity and solubility were excellent for our click-chemistry conjugation assays.
2/4/2018
— Dr. Victoria Brown, ADC Chemist (UK)
Reliable batch-to-batch performance of DBCO-PEG4-vc-PAB-MMAF ensured reproducibility.
7/8/2022
— Dr. Stefan Weber, Medicinal Chemist (Germany)
Fast delivery and detailed QC documentation for DBCO-PEG4-vc-PAB-MMAF improved lab workflow.
26/6/2019
— Dr. Emily Grant, Biochemist (Canada)
Technical support for DBCO-PEG4-vc-PAB-MMAF clarified optimal handling conditions.
10/5/2022
— Dr. Thomas Wright, Lead Scientist (USA)
High-purity DBCO-PEG4-vc-PAB-MMAF allowed consistent ADC conjugation across experiments.
— Dr. Isabelle Moreau, Research Scientist (France)
Professional guidance combined with reliable DBCO-PEG4-vc-PAB-MMAF quality accelerated research timelines.
11/9/2021
DBCO-PEG4-vc-PAB-MMAF
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DBCO-PEG4-vc-PAB-MMAF
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