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CAS No.:
Cat No.: BADC-00753
4.5 
DBCO-PEG4-vc-PAB-Duocarmycin SA is a drug-linker conjugate for ADC by using Duocarmycin SA (a potent antitumor antibiotic), linked via DBCO-PEG4-vc-PAB.
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DBCO-PEG4-vc-PAB-Duocarmycin SA is a defined ADC Cytotoxin with Linker, combining the highly cytotoxic Duocarmycin SA payload with a cleavable vc-PAB ADC Linker and a PEG4 spacer. This design ensures that the ADC payload remains stable during systemic circulation and is released specifically inside antigen-expressing tumor cells. As a potent ADC Cytotoxin, DBCO-PEG4-vc-PAB-Duocarmycin SA delivers Duocarmycin SA efficiently, supporting DNA minor-groove binding and crosslinking, which induces apoptosis while maintaining controlled intracellular release through the cleavable linker.
The cytotoxic mechanism of DBCO-PEG4-vc-PAB-Duocarmycin SA involves antibody-mediated targeting and internalization into cells expressing the target antigen. Within lysosomes, the vc-PAB linker is cleaved by proteases, releasing the Duocarmycin SA payload. This selective intracellular release ensures the ADC payload exerts its DNA-alkylating activity in tumor cells, achieving potent cytotoxic effects while minimizing systemic exposure. The PEG4 spacer improves solubility and provides flexibility, supporting efficient conjugation and functional activity.
DBCO-PEG4-vc-PAB-Duocarmycin SA allows stable conjugation to antibodies through the DBCO functional group, generating homogeneous ADC Cytotoxins with Linker. The cleavable vc-PAB linker and PEG4 spacer enable predictable intracellular payload release and reproducible cytotoxic performance. Its chemical properties, including solubility, linker stability, and maleimide-free conjugation chemistry, facilitate controlled ADC assembly and reliable delivery of the Duocarmycin SA payload.
Applications of DBCO-PEG4-vc-PAB-Duocarmycin SA are focused on its use as a defined ADC payload-linker combination for constructing homogeneous antibody-drug conjugates. The protease-sensitive linker and PEG4 spacer enable controlled intracellular release of Duocarmycin SA, ensuring consistent DNA crosslinking and cytotoxicity. This reagent provides precise payload delivery in ADC Cytotoxins with Linker, supporting potent and targeted therapeutic effects in oncology research and ADC development.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00811 | Duocarmycin DM free base | 1116745-06-2 | |
| BADC-00337 | Seco-Duocarmycin TM | 1142188-60-0 | |
| BADC-00223 | Duocarmycin A | 118292-34-5 | |
| BADC-00362 | Duocarmycin B1 | 124325-93-5 | |
| BADC-00341 | Seco-Duocarmycin SA | 152785-82-5 | |
| BADC-00605 | Duocarmycin TM | 157922-77-5 | |
| BADC-00332 | Seco-DuocarmycinCN | 1613286-54-6 | |
| BADC-00333 | Seco-DuocarmycinDMG | 1613286-55-7 | |
| BADC-00342 | Seco-Duocarmycin MA | 1613286-57-9 | |
| BADC-00609 | Duocarmycin MB | 1613286-58-0 |
What is DBCO-PEG4-vc-PAB-Duocarmycin SA?
DBCO-PEG4-vc-PAB-Duocarmycin SA is a duocarmycin-based cytotoxic payload designed for use in antibody-drug conjugates (ADCs). It incorporates a dibenzocyclooctyne (DBCO) group for click chemistry conjugation, a PEG4 solubilizer, a valine-citrulline (vc) cleavable linker, and a PAB self-immolative spacer for controlled intracellular release.
8/7/2019
We would like to know how DBCO-PEG4-vc-PAB-Duocarmycin SA releases the active payload.
The valine-citrulline (vc) linker in DBCO-PEG4-vc-PAB-Duocarmycin SA is cleaved by lysosomal proteases upon internalization. Following cleavage, the PAB spacer undergoes self-immolation, releasing the duocarmycin payload to exert cytotoxic effects in target cells.
23/9/2017
Could you kindly explain the advantages of PEG4 in this payload?
PEG4 in DBCO-PEG4-vc-PAB-Duocarmycin SA improves aqueous solubility and reduces aggregation. This enhances pharmacokinetics, allows higher drug-to-antibody ratios, and ensures stable delivery of the cytotoxic payload in ADC formulations.
12/7/2016
Could you kindly advise which conjugation strategy is used with DBCO-PEG4-vc-PAB-Duocarmycin SA?
The DBCO group enables strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry with azide-modified antibodies. This bioorthogonal reaction allows site-specific and efficient ADC conjugation without compromising antibody function.
18/9/2020
Dear BOC Sciences, what research applications are supported by DBCO-PEG4-vc-PAB-Duocarmycin SA?
It is primarily used in ADC development for evaluating linker stability, payload release efficiency, cytotoxicity, and pharmacokinetics in preclinical oncology models, facilitating the design of potent and selective targeted therapies.
7/12/2017
— Dr. Caroline Lewis, ADC Lead Scientist (UK)
DBCO-PEG4-vc-PAB-Duocarmycin SA delivered high reactivity and consistent batch quality for our ADC studies.
12/7/2016
— Mr. Victor Nguyen, Research Chemist (USA)
Excellent solubility and minimal aggregation. DBCO-PEG4-vc-PAB-Duocarmycin SA integrated well into workflow.
7/12/2017
— Dr. Isabelle Martin, Medicinal Chemist (France)
Reliable performance with predictable DAR. This linker reduced unwanted side reactions.
18/9/2020
— Prof. Lars Andersen, Biochemistry Professor (Denmark)
Delivered on time with clear documentation. Integration into conjugation was seamless.
8/7/2019
— Dr. Emilia Rossi, Conjugation Specialist (Italy)
DBCO-PEG4-vc-PAB-Duocarmycin SA’s stability and reactivity profile matched our project requirements perfectly.
— Mr. Thomas Lee, Senior Scientist (USA)
Smooth ADC assembly across multiple trials. Highly reactive and pure linker.
23/9/2017
DBCO-PEG4-vc-PAB-Duocarmycin SA
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DBCO-PEG4-vc-PAB-Duocarmycin SA
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