Name: DBCO-PEG3-oxyamine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

IUPAC Name

Canonical SMILES

C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCC(=O)NCCOCCOCCOCCNC(=O)CON

InChI

InChI=1S/C29H36N4O7/c30-40-22-28(35)32-14-16-38-18-20-39-19-17-37-15-13-31-27(34)11-12-29(36)33-21-25-7-2-1-5-23(25)9-10-24-6-3-4-8-26(24)33/h1-8H,11-22,30H2,(H,31,34)(H,32,35)

InChIKey

JRBITMATWRXIQO-UHFFFAOYSA-N

Solubility

10 mm in DMSO

Appearance

Light yellow oil

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature, or blue ice upon request.

Storage

Store at -20 °C, keep in dry and avoid sunlight.

DBCO-PEG3-oxyamine, a versatile chemical linker, finds wide-ranging applications in bioconjugation. Here are four key applications of DBCO-PEG3-oxyamine:

Bioconjugate Chemistry: Serving as a linchpin in biomolecular connections, DBCO-PEG3-oxyamine links proteins, peptides, and nucleic acids to each other or to surfaces with finesse. This stable and selective chemical bond facilitates the assembly of intricate molecular structures, essential for the advancement of cutting-edge diagnostics, therapeutics, and biosensors.

Drug Delivery: At the forefront of targeted drug delivery, DBCO-PEG3-oxyamine plays a pivotal role in coupling therapeutic agents to targeting molecules like antibodies or ligands. This union guides drugs precisely to their intended cellular destinations, minimizing off-target effects and amplifying therapeutic efficacy. The incorporation of PEGylation not only enhances solubility and stability but also elevates the effectiveness of drug conjugates.

Immunoassay Development: Integral to immunoassays, DBCO-PEG3-oxyamine acts as a linchpin for attaching antigens or antibodies to solid supports or detection labels. This attachment boosts the sensitivity and specificity of assays, crucial for detecting biomarkers or pathogens with accuracy. The heightened assay performance positions DBCO-PEG3-oxyamine as a cornerstone in clinical diagnostics and research endeavors.

Cellular Imaging: In the realm of cellular imaging, DBCO-PEG3-oxyamine shines as a vital component for linking fluorescent dyes or probes to biomolecules or cell surface markers. This linkage enables real-time visualization and tracking of specific cells, proteins, or biological processes. Enhanced imaging capabilities are essential for deciphering cellular functions, unraveling disease progression, and probing the impacts of novel therapeutics.

Catalog	Product Name	CAS
BADC-01010	DBCO-PEG4-amine	1840886-10-3
BADC-01017	DBCO-PEG5-acid	1870899-46-9
BADC-01536	DBCO-Peg4-VC-PAB-MMAE	2129164-91-4
BADC-01073	DBCO-PEG5-NHS ester	2144395-59-3
BADC-01077	DBCO-PEG4-DBCO	2182601-68-7
BADC-00863	DBCO-PEG4-Val-Cit-PAB-MMAF	2244602-23-9
BADC-01089	DBCO-PEG3 acetic-EVCit-PAB	2253947-17-8
BADC-00868	DBCO-(PEG2-VC-PAB-MMAE)2	2259318-55-1
BADC-00762	DBCO-PEG4-VC-PAB-DMEA-PNU159682	2259318-56-2
BADC-00751	DBCO-PEG4-MMAF	2360411-65-8

What is DBCO-PEG3-oxyamine used for in bioconjugation?

DBCO-PEG3-oxyamine is a bioorthogonal linker used in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions. It allows efficient conjugation of azide-containing biomolecules and antibodies without requiring copper catalysts, reducing cytotoxicity and preserving protein function.

29/7/2016

Could you advise how stable DBCO-PEG3-oxyamine is during storage?

DBCO-PEG3-oxyamine should be stored at -20°C, protected from light and moisture. The PEG3 spacer enhances solubility, while proper storage preserves the DBCO functionality for reliable click chemistry applications.

21/7/2022

Dear BOC Sciences, which biomolecules are compatible with DBCO-PEG3-oxyamine?

It is compatible with azide-functionalized antibodies, peptides, and small molecules. The oxyamine group allows subsequent oxime ligation, making it a versatile tool for modular ADC construction and site-specific labeling.

3/10/2016

Good morning! Can DBCO-PEG3-oxyamine be used for in vivo studies?

Yes, DBCO-PEG3-oxyamine is suitable for preclinical studies due to its bioorthogonal reactivity and minimal cytotoxicity. The PEG spacer improves solubility and circulation stability, supporting efficient ADC conjugation in biological systems.

6/9/2019

Good morning! What are the recommended storage conditions and stability considerations for DBCO-PEG3-oxyamine?

DBCO-PEG3-oxyamine should be stored at -20°C in a dry, inert atmosphere to prevent degradation. Avoid repeated freeze-thaw cycles and exposure to moisture. Aliquoting the product is recommended for repeated use, ensuring consistent performance in bioconjugation reactions and maintaining the reactive oxyamine functionality.

22/9/2017

— Dr. Jonathan White, Medicinal Chemist (UK)

DBCO-PEG3-oxyamine enabled efficient strain-promoted conjugation in our ADC workflows.

3/10/2016

— Ms. Anna Hoffmann, Biochemist (Germany)

Excellent lot-to-lot consistency ensured predictable multi-step synthesis.

22/9/2017

— Dr. William Parker, Senior Scientist (USA)

High purity and yields allowed smooth incorporation into complex linkers.

6/9/2019

— Dr. Elise Moreau, Chemist (France)

Integration into our linker designs was straightforward and reliable.

29/7/2016

— Dr. Mark Johnson, Research Scientist (USA)

The product facilitated innovative linker designs enhancing solubility and stability.

— Dr. Olivia Green, Bioconjugation Scientist (UK)

DBCO-PEG3-oxyamine facilitated rapid and selective click chemistry conjugations. The product arrived with detailed datasheets and high reproducibility.

21/7/2022