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CAS No.: 1807518-67-7
Cat No.: BADC-01001
Purity: ≥95%
4.5 
Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Structure of 1807518-67-7
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Bromoacetamido-PEG4-acid is a versatile reagent used in various bioconjugation and chemical biology applications. Here are some key applications of Bromoacetamido-PEG4-acid:
Protein Labeling: Bromoacetamido-PEG4-acid is commonly used to label proteins with fluorescent dyes or other probes. The bromoacetamide group reacts specifically with cysteine residues, forming a stable covalent bond. This enables researchers to track and study protein localization and interactions in living cells.
Drug Delivery: In drug delivery, Bromoacetamido-PEG4-acid is employed to conjugate therapeutic agents to targeting molecules such as antibodies. The PEG (polyethylene glycol) linker increases solubility and reduces immunogenicity, enhancing the efficacy and safety of the drug. This strategy is particularly useful in creating targeted therapies for cancer and other diseases.
Surface Functionalization: Bromoacetamido-PEG4-acid is used to modify surfaces of nanoparticles, biomaterials, and other devices. By attaching various ligands or biomolecules, scientists can create functional surfaces with specific properties. This application is crucial for developing biosensors, diagnostic tools, and tissue engineering scaffolds.
Chemical Biology Research: In chemical biology, Bromoacetamido-PEG4-acid serves as a tool for creating reversible or permanent modifications on biomolecules. Researchers use it to study protein-protein interactions, enzyme activities, and other cellular processes. The flexibility of the PEG4 spacer allows for minimal steric hindrance, making it ideal for complex biological systems.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00572 | Bromoacetamido-PEG4-NHS ester | 1260139-70-5 | |
| BADC-00940 | Br-PEG4-NHBoc | 1392499-32-9 | |
| BADC-01132 | Bromo-PEG2-azide | 530151-56-5 | |
| BADC-01136 | Br-PEG4-COOtBu | 564476-32-0 |
Bromoacetamido-PEG4-acid
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Bromoacetamido-PEG4-acid
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