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Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01001 | -- | $-- | Inquiry |
Bromoacetamido-PEG4-acid is a versatile reagent used in various bioconjugation and chemical biology applications. Here are some key applications of Bromoacetamido-PEG4-acid:
Protein Labeling: Bromoacetamido-PEG4-acid is commonly used to label proteins with fluorescent dyes or other probes. The bromoacetamide group reacts specifically with cysteine residues, forming a stable covalent bond. This enables researchers to track and study protein localization and interactions in living cells.
Drug Delivery: In drug delivery, Bromoacetamido-PEG4-acid is employed to conjugate therapeutic agents to targeting molecules such as antibodies. The PEG (polyethylene glycol) linker increases solubility and reduces immunogenicity, enhancing the efficacy and safety of the drug. This strategy is particularly useful in creating targeted therapies for cancer and other diseases.
Surface Functionalization: Bromoacetamido-PEG4-acid is used to modify surfaces of nanoparticles, biomaterials, and other devices. By attaching various ligands or biomolecules, scientists can create functional surfaces with specific properties. This application is crucial for developing biosensors, diagnostic tools, and tissue engineering scaffolds.
Chemical Biology Research: In chemical biology, Bromoacetamido-PEG4-acid serves as a tool for creating reversible or permanent modifications on biomolecules. Researchers use it to study protein-protein interactions, enzyme activities, and other cellular processes. The flexibility of the PEG4 spacer allows for minimal steric hindrance, making it ideal for complex biological systems.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
