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Bis-Tos-(2-hydroxyethyl disulfide)

  CAS No.: 69981-39-1   Cat No.: BADC-01148   Purity: >98.0% 4.5  

Bis-Tos-(2-hydroxyethyl disulfide) is a bifunctional disulfide ADC linker with tosylate leaving groups, enabling cleavable conjugation and controlled intracellular drug release in targeted antibody therapeutics.

Bis-Tos-(2-hydroxyethyl disulfide)

Structure of 69981-39-1

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Category
ADC Linker
Molecular Formula
C18H22O6S4
Molecular Weight
462.62
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
Disulfanediylbis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)
IUPAC Name
Canonical SMILES
CC1=CC=C(C=C1)S(=O)(=O)OCCSSCCOS(=O)(=O)C2=CC=C(C=C2)C
InChI
InChI=1S/C18H22O6S4/c1-15-3-7-17(8-4-15)27(19,20)23-11-13-25-26-14-12-24-28(21,22)18-9-5-16(2)6-10-18/h3-10H,11-14H2,1-2H3
InChIKey
BBGVCMPJFAYXLJ-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Melting Point
>255°C (dec.)
PSA
154.10000
Appearance
Yellow solid
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Boiling Point
823°C
Form
Solid

One of the key applications of Bis-Tos-(2-hydroxyethyl disulfide) is in the field of pharmaceuticals, particularly in drug synthesis. This compound, with its disulfide bond, has been found to act as a reducing agent and a linker in the synthesis of various active pharmaceutical ingredients (APIs). Its ability to undergo redox reactions makes it suitable for constructing complex molecules that are essential in medicine. For instance, it can aid in the formation of drugs that target oxidative stress or have functional groups that need to be protected during medicinal chemical synthesis. This makes Bis-Tos-(2-hydroxyethyl disulfide) a valuable tool in the development of new therapeutics.

Another significant application of Bis-Tos-(2-hydroxyethyl disulfide) is in biochemical research, especially in protein chemistry. The disulfide bonds mimic the natural disulfide bridges found in proteins, making this compound useful in the study of protein folding and stability. Researchers use it to modify protein structures or to create synthetic peptides with specific disulfide linkages. This helps in understanding how proteins maintain their structure and function, and can also be used to develop protein-based drugs or enzymes with enhanced properties.

Bis-Tos-(2-hydroxyethyl disulfide) also finds application in the field of materials science, particularly in the development of advanced polymeric materials. The compound can be used as a crosslinking agent in the formation of polymers, imparting unique mechanical and thermal properties. These properties are essential for creating materials that are strong yet flexible, heat-resistant, or possess specific electrical properties. Such polymers are useful in a wide range of applications, from biomedical devices and food packaging to electronics and structural components. The ability to finely tune the properties of these polymers opens up numerous possibilities for innovation in materials science.

Lastly, Bis-Tos-(2-hydroxyethyl disulfide) is utilized in environmental chemistry, primarily for pollution control and remediation. Its disulfide bonds can interact with various environmental pollutants, such as heavy metals and organic contaminants, facilitating their removal from wastewater or soil. This compound can be incorporated into filtration systems or used in chemical treatments to detoxify polluted environments. The use of Bis-Tos-(2-hydroxyethyl disulfide) in this context highlights its importance in developing sustainable solutions for environmental protection, contributing to cleaner water and soil, and ultimately protecting ecosystems and human health.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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