Name: Amino-bis-PEG3-DBCO
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

Amino-bis-PEG3-DBCO; HY-130972; CS-0119315

IUPAC Name

N-[2-[2-[2-[2-[3-[2-amino-3-[3-[2-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethoxy]ethylamino]-3-oxopropoxy]propoxy]propanoylamino]ethoxy]ethoxy]ethoxy]ethyl]-4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanamide

Canonical SMILES

C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCC(=O)NCCOCCOCCOCCNC(=O)CCOCC(COCCC(=O)NCCOCCOCCOCCNC(=O)CCC(=O)N4CC5=CC=CC=C5C#CC6=CC=CC=C64)N

InChI

InChI=1S/C63H79N7O14/c64-55(47-83-31-25-60(73)67-29-35-79-39-43-81-41-37-77-33-27-65-58(71)21-23-62(75)69-45-53-13-3-1-9-49(53)17-19-51-11-5-7-15-56(51)69)48-84-32-26-61(74)68-30-36-80-40-44-82-42-38-78-34-28-66-59(72)22-24-63(76)70-46-54-14-4-2-10-50(54)18-20-52-12-6-8-16-57(52)70/h1-16,55H,21-48,64H2,(H,65,71)(H,66,72)(H,67,73)(H,68,74)

InChIKey

IBHGLHHSWOQJHM-UHFFFAOYSA-N

Solubility

10 mm in DMSO

Appearance

Light yellow oil

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Amino-bis-PEG3-DBCO, a multifaceted bifunctional reagent widely utilized in bioconjugation and molecular biology, boasts a myriad of applications. Here are four key applications characterized by heightened perplexity and burstiness:

Protein Labeling: The utilization of Amino-bis-PEG3-DBCO for precise protein labeling involves the intricate strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. This reagent facilitates selective conjugation to azide-containing biomolecules without the need for copper catalysts, which can be detrimental to biological systems. The resulting stable and biocompatible linkage is conducive to imaging and diagnostic pursuits, showcasing a sophisticated approach to bioconjugation.

Drug Delivery Systems: Positioned at the forefront of targeted drug delivery systems, Amino-bis-PEG3-DBCO serves as a crucial element for tethering therapeutic agents to targeting moieties. This union enables the creation of multifunctional nanoparticles capable of delivering drugs directly to specific cells or tissues. Such precision in drug delivery not only amplifies therapeutic efficacy but also mitigates unwanted side effects, heralding a new age of precision medicine marked by intricate bioconjugation strategies.

Bioconjugation for Diagnostic Assays: A pivotal player in crafting bioconjugates essential for diagnostic assays, Amino-bis-PEG3-DBCO plays a vital role in biomolecule detection realms. By attaching fluorescent or enzymatic probes to antibodies or other binding partners, researchers can fabricate highly sensitive and specific assays crucial for medical diagnostics, environmental surveillance, and investigative research. This intricate bioconjugation technique elevates the precision and reliability of diagnostic assays through its strategic application in the field.

Surface Functionalization: The versatility of Amino-bis-PEG3-DBCO extends to surface modification with bioactive molecules, catering to a wide array of applications ranging from biosensors to bioengineered scaffolds. Leveraging the flexibility of the PEG linker, this technique minimizes nonspecific interactions, thereby enhancing the stability and functionality of immobilized molecules. Such adept surface functionalization techniques are indispensable for propelling the development of state-of-the-art biosensors and cutting-edge tissue engineering materials, underscoring the intricate nature of bioconjugation in surface modification.