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CAS No.:
Cat No.: BADC-01875
4.5 
(2R,4S)-Boc-D-Pro(4-N3)-OH (DCHA) is a proline-derived ADC linker intermediate with azide functionalization and Boc protection, designed for bioorthogonal click conjugation in antibody-drug conjugates. It supports site-specific payload attachment with enhanced stability. Keywords: ADC linker, proline linker, azide linker, Boc protection, click chemistry.
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(2R,4S)-Boc-D-Pro(4-N3)-OH (DCHA), a versatile chemical compound with diverse biochemical and pharmaceutical applications, finds itself at the forefront of innovation. Here are four key applications highlighted with a high degree of perplexity and burstiness:
Peptide Synthesis: Serving as a crucial component in peptide synthesis, (2R,4S)-Boc-D-Pro(4-N3)-OH (DCHA) acts as a foundational piece in constructing complex peptide sequences. It enables the precise incorporation of modifications or functional groups into peptides, facilitating the creation of customized sequences for a myriad of applications. The Boc protection group associated with this compound plays a pivotal role in selective deprotection steps during the intricate process of peptide assembly.
Drug Design: In the realm of pharmaceutical research, (2R,4S)-Boc-D-Pro(4-N3)-OH (DCHA) emerges as a valuable asset for designing and synthesizing novel drug candidates. Its unique structural characteristics open doors to creating compounds that interact with target proteins in specific ways. Researchers leverage this compound to craft inhibitors or modulators that target biological pathways implicated in diverse diseases, thus pushing the boundaries of drug discovery and development.
Chemical Biology: Embedded within the realm of chemical biology, (2R,4S)-Boc-D-Pro(4-N3)-OH (DCHA) plays a pivotal role in unraveling the intricate functions of proteins. By integrating this compound into peptides or small molecules, scientists can delve into the realm of protein-protein interactions and enzyme activities, shedding light on fundamental biological processes. The presence of the azide group within (2R,4S)-Boc-D-Pro(4-N3)-OH (DCHA) sets the stage for subsequent click chemistry reactions, facilitating the attachment of diverse probes or tags, thereby enabling innovative research methodologies.
Immunology Research: Positioned at the forefront of immunology research, (2R,4S)-Boc-D-Pro(4-N3)-OH (DCHA) emerges as a key player in the development of vaccine candidates and immunotherapies. Through the incorporation of this compound into peptide-based antigens, researchers pave the way for enhancing immune responses or crafting immunogens with specific attributes. This approach proves invaluable in the realm of studying and developing vaccines aimed at combating infectious diseases and cancers, thus marking a significant advancement in the field of immunology.
(2R,4S)-Boc-D-Pro(4-N3)-OH (DCHA)
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(2R,4S)-Boc-D-Pro(4-N3)-OH (DCHA)
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