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N-(2-(2,4-Difluorophenoxy)ethyl)-4-Formylbenzamide

  CAS No.: 1226050-21-0   Cat No.: BADC-00547 4.5  

N-(2-(2,4-Difluorophenoxy)ethyl)-4-Formylbenzamide is a fluorinated aldehyde ADC linker designed for selective conjugation and increased metabolic stability, improving antibody-drug conjugate efficacy and targeted payload release.

N-(2-(2,4-Difluorophenoxy)ethyl)-4-Formylbenzamide

Structure of 1226050-21-0

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ADC Linker
Molecular Formula
C16H13F2NO3
Molecular Weight
305.28
Shipping
Room temperature

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IUPAC Name
N-[2-(2,4-difluorophenoxy)ethyl]-4-formylbenzamide
Canonical SMILES
C1=CC(=CC=C1C=O)C(=O)NCCOC2=C(C=C(C=C2)F)F
InChI
InChI=1S/C16H13F2NO3/c17-13-5-6-15(14(18)9-13)22-8-7-19-16(21)12-3-1-11(10-20)2-4-12/h1-6,9-10H,7-8H2,(H,19,21)
InChIKey
QPQVAUUDXHQQEX-UHFFFAOYSA-N
Shipping
Room temperature

N-(2-(2,4-Difluorophenoxy)ethyl)-4-Formylbenzamide is an important compound in the development of targeted therapies, particularly in the area of cancer treatment. The molecule's structural features, including the formylbenzamide group, allow for selective interactions with specific receptors or enzymes involved in tumor growth and metastasis. This makes it a key candidate for the design of targeted drug delivery systems that can deliver therapeutic agents directly to cancer cells, minimizing damage to healthy tissues and improving the efficacy of treatment.

One significant application of N-(2-(2,4-Difluorophenoxy)ethyl)-4-Formylbenzamide is in the design of small-molecule inhibitors targeting key enzymes and signaling pathways in cancer. The difluorophenoxyethyl group provides hydrophobic interactions and improves the compound's binding affinity to the target protein. By inhibiting these critical enzymes, such as kinases or proteases involved in cancer progression, the compound can potentially slow tumor growth, reduce metastasis, and enhance the overall therapeutic outcome of cancer treatments.

Additionally, N-(2-(2,4-Difluorophenoxy)ethyl)-4-Formylbenzamide plays a role in the development of diagnostic imaging agents. Its unique structure and functional groups make it suitable for modification and conjugation to imaging agents, such as fluorescent dyes or radionuclides, allowing for the specific detection of cancerous tissues. This application is particularly useful for monitoring tumor progression, evaluating the effectiveness of treatments, and guiding surgical interventions in real-time, offering precision medicine approaches in oncology.

The compound is also explored for its potential use in the design of novel anti-inflammatory agents. The formylbenzamide structure has been shown to interact with key inflammatory mediators, such as cyclooxygenases or inflammatory cytokines. By modulating these pathways, N-(2-(2,4-Difluorophenoxy)ethyl)-4-Formylbenzamide could serve as a lead compound in the development of new drugs for the treatment of chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, where targeting inflammation at the molecular level offers potential therapeutic benefits.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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