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Mal-PEG2-PFP is a PEG linker containing maleimide and PFP moieties. Maleimide is thiol-reactive and reacts between pH 6.5 and 7.5 to form thiol ester bonds. PFP moiety is amine-reactive and is less susceptible to undergoing hydrolysis. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00452 | -- | $-- | Inquiry |
Mal-PEG2-PFP, a versatile cross-linking reagent, finds its utility across a spectrum of biochemical and biomedical applications.
Protein Conjugation: Mal-PEG2-PFP emerges as a stalwart in attaching polyethylene glycol (PEG) chains to proteins and peptides. This modification not only amplifies the solubility, stability, and pharmacokinetics of therapeutic proteins but also curtails immunogenicity. PEGylation stands poised to revolutionize the therapeutic landscape of protein-based drugs, enhancing their efficacy manifold.
Surface Modification: Mal-PEG2-PFP assumes a pivotal role in surface modification endeavors. Utilized to transform implants or biosensors, this reagent bolsters biocompatibility and curbs protein adsorption. The hydrophilic shield erected by PEG chains mitigates unsolicited interactions with biomolecules, thereby augmenting the resilience and longevity of medical devices in physiological milieus.
Bioorthogonal Chemistry: Mal-PEG2-PFP shines as a linchpin in bioorthogonal chemistry, facilitating reactions within living organisms sans disruption to native biochemical processes. This capability enables the targeted attachment of probes or therapeutic agents to biomolecules in complex systems, propelling advancements in tailored drug delivery and imaging techniques.
Drug Delivery Systems: Stepping into the realm of drug delivery systems, Mal-PEG2-PFP assumes a pivotal role in crafting nanoparticles and liposomes for therapeutic applications. Through the conjugation of drugs to PEGylated carriers, researchers engineer systems that promise targeted delivery, prolonged circulation time, and mitigated toxicity.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
