Mal-PEG2-PFP - CAS 1807512-47-5

Mal-PEG2-PFP - CAS 1807512-47-5 Catalog number: BADC-00452

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Mal-PEG2-PFP is a PEG linker containing maleimide and PFP moieties. Maleimide is thiol-reactive and reacts between pH 6.5 and 7.5 to form thiol ester bonds. PFP moiety is amine-reactive and is less susceptible to undergoing hydrolysis. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media.

Category
ADCs Linker
Product Name
Mal-PEG2-PFP
CAS
1807512-47-5
Catalog Number
BADC-00452
Molecular Formula
C17H14F5NO6
Molecular Weight
423.29
Purity
≥98%
Mal-PEG2-PFP

Ordering Information

Catalog Number Size Price Quantity
BADC-00452 -- $-- Inquiry
Description
Mal-PEG2-PFP is a PEG linker containing maleimide and PFP moieties. Maleimide is thiol-reactive and reacts between pH 6.5 and 7.5 to form thiol ester bonds. PFP moiety is amine-reactive and is less susceptible to undergoing hydrolysis. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media.
Synonyms
Mal-PEG2-PFP ester; Perfluorophenyl 3-(2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethoxy)propanoate; Perfluorophenyl 3-(2-(2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)ethoxy)ethoxy)propanoate; Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester
IUPAC Name
(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]propanoate
Canonical SMILES
C1=CC(=O)N(C1=O)CCOCCOCCC(=O)Oc2c(c(c(c(c2F)F)F)F)F
InChI
InChI=1S/C17H14F5NO6/c18-12-13(19)15(21)17(16(22)14(12)20)29-11(26)3-5-27-7-8-28-6-4-23-9(24)1-2-10(23)25/h1-2H,3-8H2
InChIKey
YMKYKJKJMZSGEN-UHFFFAOYSA-N
Density
1.5±0.1 g/cm3
Solubility
Soluble in DCM, DMF, DMSO
Appearance
Soild powder
Shipping
Room temperature
Storage
Store at 2-8°C
Boiling Point
493.1±45.0°C at 760 mmHg

Mal-PEG2-PFP, a versatile cross-linking reagent, finds its utility across a spectrum of biochemical and biomedical applications.

Protein Conjugation: Mal-PEG2-PFP emerges as a stalwart in attaching polyethylene glycol (PEG) chains to proteins and peptides. This modification not only amplifies the solubility, stability, and pharmacokinetics of therapeutic proteins but also curtails immunogenicity. PEGylation stands poised to revolutionize the therapeutic landscape of protein-based drugs, enhancing their efficacy manifold.

Surface Modification: Mal-PEG2-PFP assumes a pivotal role in surface modification endeavors. Utilized to transform implants or biosensors, this reagent bolsters biocompatibility and curbs protein adsorption. The hydrophilic shield erected by PEG chains mitigates unsolicited interactions with biomolecules, thereby augmenting the resilience and longevity of medical devices in physiological milieus.

Bioorthogonal Chemistry: Mal-PEG2-PFP shines as a linchpin in bioorthogonal chemistry, facilitating reactions within living organisms sans disruption to native biochemical processes. This capability enables the targeted attachment of probes or therapeutic agents to biomolecules in complex systems, propelling advancements in tailored drug delivery and imaging techniques.

Drug Delivery Systems: Stepping into the realm of drug delivery systems, Mal-PEG2-PFP assumes a pivotal role in crafting nanoparticles and liposomes for therapeutic applications. Through the conjugation of drugs to PEGylated carriers, researchers engineer systems that promise targeted delivery, prolonged circulation time, and mitigated toxicity.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Trastuzumab-MC-MMAE | Mal-PEG2-PFP
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