Bis-PEG6-NHS ester - CAS 1526718-98-8
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Bis-PEG6-NHS ester - CAS 1526718-98-8 Catalog number: BADC-00960

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Bis-PEG6-NHS ester is a non-cleavable 6-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).

Category
ADCs Linker
Product Name
Bis-PEG6-NHS ester
CAS
1526718-98-8
Catalog Number
BADC-00960
Molecular Formula
C24H36N2O14
Molecular Weight
576.55
Bis-PEG6-NHS ester

Ordering Information

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BADC-00960 -- $--
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Description
Bis-PEG6-NHS ester is a non-cleavable 6-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).
Synonyms
NHS-PEG6-NHS; 4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester; Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate; Di-NHS Ester-PEG6; 1,1'-[(1,22-Dioxo-4,7,10,13,16,19-hexaoxadocosane-1,22-diyl)bis(oxy)]di(2,5-pyrrolidinedione); 2,5-Pyrrolidinedione, 1,1'-[(1,22-dioxo-4,7,10,13,16,19-hexaoxadocosane-1,22-diyl)bis(oxy)]bis-
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O
InChI
InChI=1S/C24H36N2O14/c27-19-1-2-20(28)25(19)39-23(31)5-7-33-9-11-35-13-15-37-17-18-38-16-14-36-12-10-34-8-6-24(32)40-26-21(29)3-4-22(26)30/h1-18H2
InChIKey
FDLGRFGWAMAWTE-UHFFFAOYSA-N
Density
1.4±0.1 g/cm3
Solubility
Soluble in DCM, DMSO
Flash Point
352.6±34.3 °C
Index Of Refraction
1.529
LogP
-5.30
Vapor Pressure
0.0±2.0 mmHg at 25°C
Biological Activity
Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Appearance
Pale Yellow or Colorless Oily Matter
Purity
≥95%
Shelf Life
-20℃ 3 years powder; -80℃ 2 years in solvent
Shipping
Room temperature
Storage
Store at 2-8°C
Boiling Point
659.4±65.0°C at 760 mmHg
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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