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CAS No.: 723340-57-6
Cat No.: BADC-01617
4.5 
ADC toxin 1 is an ADC cytotoxin with anti-cancer activities. ADC toxin 1 is against HCT-116 and PSN1 cells growth with both IC50 values of 0.86 µM.
Structure of 723340-57-6
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ADC Toxin 1 is a chemically defined cytotoxic agent designed as an ADC payload for use in antibody-drug conjugates. Its mechanism involves the disruption of microtubule dynamics, leading to mitotic arrest and apoptosis in proliferating tumor cells. The molecular structure of ADC Toxin 1 enables efficient conjugation to monoclonal antibodies through cleavable or non-cleavable linkers, facilitating precise intracellular delivery of cytotoxic activity.
Within antibody-drug conjugates, ADC Toxin 1 is attached to antibodies via linker chemistries that provide systemic stability and controlled release within target cells. Upon antibody-mediated internalization, enzymatic or chemical cleavage liberates the payload, enabling direct interaction with intracellular targets. This mechanism ensures site-specific cytotoxicity and reduces off-target effects, supporting controlled therapeutic outcomes in tumor-targeted applications.
Applications of ADC Toxin 1 include incorporation into ADCs targeting a range of hematologic malignancies and solid tumors. Its compatibility with various linker systems allows optimization of intracellular release kinetics, antibody conjugation stability, and pharmacokinetic profiles. ADC Toxin 1 exhibits defined cytotoxic potency in target-expressing cell lines and supports the development of ADCs with precise antitumor mechanisms and predictable therapeutic performance.
What is ADC toxin 1?
ADC toxin 1 is a general term for a potent cytotoxic payload used in experimental antibody-drug conjugates. It is designed to disrupt key cellular processes, induce apoptosis, and serve as a model payload in preclinical ADC research.
1/7/2017
Could you explain how ADC toxin 1 functions in ADCs?
ADC toxin 1 is conjugated to targeting antibodies, allowing selective internalization into cancer cells. Once inside, it interferes with critical cellular pathways, leading to apoptosis and providing a controlled model for ADC development.
22/3/2019
We are interested in the research applications of ADC toxin 1. Could you advise?
ADC toxin 1 is used to evaluate antibody conjugation strategies, payload potency, and intracellular delivery mechanisms. It supports optimization of preclinical ADC designs for cancer therapy research.
22/8/2022
What are the chemical features of ADC toxin 1?
ADC toxin 1 is a small molecule with functional groups suitable for stable conjugation to antibodies. Its chemical properties allow efficient intracellular release and potent cytotoxic activity in target cells.
12/8/2019
Dear team, what laboratory precautions are needed when handling ADC toxin 1?
Handling ADC toxin 1 requires strict safety protocols, including use of PPE, containment systems, and controlled waste disposal, to prevent exposure and ensure safe ADC research practices.
25/5/2016
— Dr. James Parker, Lead Scientist (USA)
ADC toxin 1 from BOC Sciences arrived with excellent purity, supporting our ADC projects.
22/8/2022
— Dr. Emily Carter, Pharmacology Researcher (USA)
The ADC toxin 1 offered by BOC Sciences showed excellent solubility and consistent biological activity in our tests. It’s a reliable option for ADC development.
25/5/2016
— Mr. Thomas Müller, CMC Specialist (Germany)
We chose ADC toxin 1 for pilot conjugation work and were impressed with the documentation package, which met all compliance standards.
12/8/2019
— Ms. Sophie Dubois, Laboratory Head (France)
BOC Sciences provided ADC toxin 1 with high purity and timely delivery. This reliability supported our preclinical studies greatly.
1/7/2017
— Dr. Michael Brown, Senior Biologist (UK)
Our team has tested ADC toxin 1 in multiple conjugation systems and consistently achieved robust results. We value their dependable supply chain.
— Mr. Luca Romano, Biotech Project Manager (Italy)
The performance of ADC toxin 1 was impressive, and the support team answered all of our technical queries quickly and professionally.
22/3/2019
ADC toxin 1
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ADC toxin 1
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