4-pentynoic acid succinimidyl ester - CAS 132178-37-1

4-pentynoic acid succinimidyl ester - CAS 132178-37-1 Catalog number: BADC-00435

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4-Pentynoic acid succinimidyl ester is a biomedicine product extensively utilized in the pharmaceutical industry. It acts as a pivotal reagent facilitating the derivatization of diverse drugs and molecules. This compound has the ability to form stable amide bonds and is an important tool in drug discovery and bioconjugation research. The remarkable versatility of this compound fuels the advancement of targeted therapeutic approaches, diagnostic instruments, and drug conveyance mechanisms.

Category
ADCs Linker
Product Name
4-pentynoic acid succinimidyl ester
CAS
132178-37-1
Catalog Number
BADC-00435
Molecular Formula
C9H9NO4
Molecular Weight
195.17
4-pentynoic acid succinimidyl ester

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Description
4-Pentynoic acid succinimidyl ester is a biomedicine product extensively utilized in the pharmaceutical industry. It acts as a pivotal reagent facilitating the derivatization of diverse drugs and molecules. This compound has the ability to form stable amide bonds and is an important tool in drug discovery and bioconjugation research. The remarkable versatility of this compound fuels the advancement of targeted therapeutic approaches, diagnostic instruments, and drug conveyance mechanisms.
Synonyms
(2,5-dioxopyrrolidin-1-yl) pent-4-ynoate;
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) pent-4-ynoate
Canonical SMILES
C#CCCC(=O)ON1C(=O)CCC1=O
InChI
InChI=1S/C9H9NO4/c1-2-3-4-9(13)14-10-7(11)5-6-8(10)12/h1H,3-6H2
InChIKey
VLQOCPXVAZTWQR-UHFFFAOYSA-N
Appearance
Soild powder
Purity
≥98%
Shipping
Room temperature, or blue ice upon request.
1. Fabrication of device with poly(N-isopropylacrylamide)-b-ssDNA copolymer brush for resistivity study
Chih-Chia Cheng, May-Show Chen, Jem-Kun Chen, Yi-Zu Liu, Shih-Hsun Chen J Nanobiotechnology . 2017 Oct 5;15(1):68. doi: 10.1186/s12951-017-0303-4.
In this study, we grafted bromo-terminated poly(N-isopropylacrylamide) (PNIPAAm) brushes onto thin gold films deposited on silicon, and then reacted with NaN3to produce azido-terminated PNIPAAm brushes. A probe sequence of single-stranded DNA (ssDNA) with a 4-pentynoic acid succinimidyl ester unit was grafted onto the azido-terminated PNIPAAm brushes through a click reaction, resulting in the formation of block copolymer brushes. The PNIPAAm-b-ssDNA copolymer brushes formed supramolecular complexes stabilized by bio-multiple hydrogen bonds (BMHBs), which enhanced the proton transfer and thereby decreased the resistivity of the structures. In addition, the optimal operation window for DNA detection ranges from 0 to 0.2 M of NaCl concentration. Therefore, the specimens were prepared in the PBS solution at 150 mM NaCl concentration for target hybridization. The supramolecular complex state of the PNIPAAm-b-ssDNA copolymer brushes transformed into the phase-separated state after the hybridization with 0.5 ng/µL of its target DNA sequence owing to the competition between BMHBs and complementary hydrogen bonds. This phase transformation of the PNIPAAm and probe segments inhibited the proton transfer and significantly increased the resistivity at 25 °C. Moreover, there were no significant changes in the resistivity of the copolymer brushes after hybridization with the target sequence at 45 °C. These results indicated that the phase-separated state of the PNIPAAm-b-ssDNA copolymer brushes, which was generally occurred above the LCST, can be substantially generated after hybridization with its target DNA sequence. By performing the controlled experiments, in the same manner, using another sequence with lengths similar to that of the target sequence without complementarity. In addition, the sequences featuring various degrees of complementarity were exploited to verify the phase separation behavior inside the PNIPAAm-b-ssDNA copolymer thin film.
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This equation is commonly abbreviated as: C1V1 = C2V2

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