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2,5-dioxopyrrolidin-1-yl 3-(4-hydroxyphenoxy)propanoate

  CAS No.: 616889-42-0   Cat No.: BADC-00682 4.5  

2,5-dioxopyrrolidin-1-yl 3-(4-hydroxyphenoxy)propanoate is an NHS ester ADC linker facilitating efficient antibody conjugation through phenolic hydroxyl groups, enhancing payload stability and targeted delivery in antibody-drug conjugates.

2,5-dioxopyrrolidin-1-yl 3-(4-hydroxyphenoxy)propanoate

Structure of 616889-42-0

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ADC Linker
Molecular Formula
C13H13NO6
Molecular Weight
279.25
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Room temperature, or blue ice upon request.

* For research and manufacturing use only. We do not sell to patients.

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Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)CCOC2=CC=C(C=C2)O
InChI
InChI=1S/C13H13NO6/c15-9-1-3-10(4-2-9)19-8-7-13(18)20-14-11(16)5-6-12(14)17/h1-4,15H,5-8H2
InChIKey
SRPYZXKPDNHJLM-UHFFFAOYSA-N
Shipping
Room temperature, or blue ice upon request.

2,5-dioxopyrrolidin-1-yl 3-(4-hydroxyphenoxy)propanoate, a versatile organic compound with diverse applications in biotechnology and medicinal chemistry. Here are four key applications with a high degree of perplexity and burstiness:

Protein Labeling: Acting as a reagent for protein labeling, this compound facilitates the exploration of protein interactions, localization, and function. By binding to specific amino acid residues, it assists researchers in tracing proteins within cells or tissues. This method enhances comprehension of various biological processes and disease mechanisms.

Drug Delivery Systems: This compound plays a pivotal role in developing sophisticated drug delivery systems. Serving as a linker or carrier molecule, it can conjugate with drugs to enhance their stability and bioavailability. This strategy is paramount for precise drug delivery, elevating the therapeutic effectiveness of pharmaceuticals.

Polymer Synthesis: Serving as an intermediary for specialized polymer synthesis, this compound contributes to various biomedical applications. Polymers incorporating this molecule showcase unique characteristics such as biocompatibility and controlled degradation rates. These attributes are advantageous in crafting medical devices, tissue engineering scaffolds, and formulations for controlled release.

Chemical Biology: In the realm of chemical biology, researchers leverage this compound to investigate enzyme activities and protein functions. By forming covalent bonds with enzyme active sites, it aids in identifying and characterizing enzymatic pathways. This knowledge is indispensable for drug discovery and comprehending metabolic processes.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: 3-((2,5-Dioxopyrrolidin-1-Yl)oxy)-3-Oxopropyl Acrylate | (2S)-p-SCN-Bn-NOTA | [(2-methylpropan-2-yl)oxycarbonylamino] 4-methylbenzenesulfonate | Fmoc-L-Lys(4-N3-Z)-OH | p-SCN-Bn-DOTA | DM1-SMCC | DM1-SPP | (2-pyridyldithio)-PEG1-hydrazine | (R)-8-Azido-2-(Fmoc-amino)octanoic acid | N-(2-((2,3-Dihydro-1H-Inden-5-yl)oxy)ethyl)-4-Formylbenzamide | 2,5-dioxopyrrolidin-1-yl 3-(4-hydroxyphenoxy)propanoate
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