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CAS No.: 1529763-58-3
Cat No.: BADC-01650
4.5 
18-Azido-stearic acid is a lipid-based ADC linker featuring an azide functional group for bioorthogonal conjugation, improving membrane interaction and payload delivery in antibody-drug conjugates. Keywords: ADC linker, azide linker, lipid linker, bioconjugation.
Structure of 1529763-58-3
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18-Azido-stearic acid, a unique functionalized fatty acid, finds diverse applications in scientific and industrial domains. Here are four key applications highlighted with high perplexity and burstiness:
Chemical Biology: In the realm of chemical biology, 18-Azido-stearic acid serves as a pivotal tool for modifying biomolecules using click chemistry. This "bio-orthogonal" approach enables selective tagging of lipids and proteins within live cells, devoid of disruption to natural cellular processes. Through such tagging, researchers delve into lipid metabolism, protein-lipid interactions, and cellular trafficking, unraveling intricate cellular dynamics.
Drug Delivery Systems: The integration of 18-Azido-stearic acid into lipid-based nanocarriers heralds innovations in advanced drug delivery systems. By leveraging this compound, targeted and controlled release of therapeutic agents is made achievable, elevating drug stability and bioavailability. Such advancements hold promise for enhancing treatment efficacy, offering novel avenues in pharmaceutical sciences.
Materials Science: Within materials science, 18-Azido-stearic acid plays a crucial role in surface functionalization and self-assembled monolayer creation. These tailored surfaces wield the power to alter material properties, be it augmenting hydrophobicity or fostering biocompatibility. Applications span the creation of biosensors, medical implants, and antifouling coatings, showcasing the versatility and impact of this compound in material engineering.
Proteomics: In the realm of proteomics, 18-Azido-stearic acid emerges as a key ally, streamlining the enrichment and identification of lipid-modified proteins. Through selective labeling and capture of proteins modified with this compound via azide-alkyne cycloaddition reactions, researchers gain insights into lipid-protein interactions. This detailed analysis is pivotal for deciphering cellular signaling intricacies and membrane dynamics, paving the way for profound discoveries in cellular biology.
18-Azido-stearic acid
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18-Azido-stearic acid
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