Mertansine, the cytotoxic component in antibody-drug conjugates, is attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker or SMCC (4-(3-mercapto-2,5-dioxo-1 pyrrolidinylmethyl)-cylohexanecarboxylic acid) linkerto create an antibody-drug conjugate. It derives from a maytansine.
Catalog Number | Size | Price | Quantity |
---|---|---|---|
BADC-00086 | 40 mg(95%+) | $298 | |
BADC-00086 | 50 mg(98%) | $419 |
NCT Number | Condition Or Disease | Phase | Start Date | Sponsor | Status |
---|---|---|---|---|---|
NCT02254005 | Breast Neoplasms | Phase 1 | 2014-10-01 | Boehringer Ingelheim | Completed |
NCT02452554 | Pleuropulmonary Blastoma | Phase 2 | 2020-09-22 | Children's Oncology Group | Active, not recruiting |
NCT02420873 | Leukemia | Phase 2 | 2018-08-28 | M.D. Anderson Cancer Center | Completed |
NCT02254044 | Carcinoma, Squamous Cell | Phase 1 | 2014-10-01 | Boehringer Ingelheim | Terminated |
NCT02725541 | Breast Cancer | Phase 2 | 2016-09-14 | Jenny C. Chang, MD | Withdrawn (loss of funding support) |
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.