Inquiry Basket
H-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01917 | -- | $-- | Inquiry |
L-4-trans-Hydroxyproline methyl ester hydrochloride is a synthetic derivative of hydroxyproline, a key amino acid found in collagen and connective tissues. This compound is particularly useful in the study of protein structure and function, as it mimics natural hydroxyproline residues found in collagen. L-4-trans-Hydroxyproline methyl ester hydrochloride is widely used in peptide synthesis, particularly in the creation of collagen-related peptides, which are essential for studying the structure and stability of collagen fibers. This application is valuable in the fields of biochemistry, molecular biology, and structural proteomics, where understanding collagen's role in diseases such as osteogenesis imperfecta and fibrosis is critical.
One of the primary applications of L-4-trans-Hydroxyproline methyl ester hydrochloride is in the design and synthesis of collagen mimetic peptides. These peptides are used to model the secondary and tertiary structures of collagen, as hydroxyproline plays a crucial role in stabilizing the collagen triple helix. By incorporating this compound into peptide sequences, researchers can study the effects of hydroxyproline modifications on collagen stability and function. This application is particularly important in drug discovery, as it allows for the development of therapeutic strategies targeting collagen-related diseases such as osteoarthritis, wound healing disorders, and tissue fibrosis.
L-4-trans-Hydroxyproline methyl ester hydrochloride is also used in the development of biomaterials, particularly those aimed at mimicking the structural and mechanical properties of collagen. Due to its ability to incorporate into synthetic peptides or proteins, this compound can be used in tissue engineering applications to create scaffolds that resemble the extracellular matrix. These scaffolds are crucial for regenerative medicine, as they promote cell adhesion, growth, and differentiation. Researchers are exploring the use of L-4-trans-Hydroxyproline methyl ester hydrochloride-based materials for the development of advanced biomaterials used in wound healing, bone regeneration, and skin tissue engineering.
Another key application of L-4-trans-Hydroxyproline methyl ester hydrochloride is in the study of post-translational modifications of collagen. Hydroxyproline residues in collagen are often modified by enzymes like prolyl hydroxylase, and understanding these modifications is critical for determining the functional properties of collagen in tissues. By using this compound in in vitro studies, researchers can investigate how different forms of hydroxyproline affect the biochemical properties of collagen and its interactions with other extracellular matrix components. This knowledge could lead to the development of new therapies for diseases that involve collagen abnormalities, such as fibrosis or Ehlers-Danlos syndrome.
Customer Support
Providing excellent 24/7 customer service and support
Project Management
Offering 100% high-quality services at all stages
Quality Assurance
Ensuring the quality and reliability of products or services
Global Delivery
Ensuring timely delivery of products worldwide
BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, non-natural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
