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Gly-PEG3-amine

  CAS No.: 2110448-97-8   Cat No.: BADC-01063   Purity: >98.0% 4.5  

Gly-PEG3-amine functions as an amino-functionalized ADC linker with PEG spacer, enabling stable antibody conjugation and improved solubility for optimized ADC design and targeted therapy applications.

Gly-PEG3-amine

Structure of 2110448-97-8

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Category
ADC Linker
Molecular Formula
C12H27N3O4
Molecular Weight
277.36
Shipping
Room temperature
Storage
Store at -5°C,keep in dry and avoid sunlight.

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
2-Amino-N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)acetamide
IUPAC Name
2-amino-N-[3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propyl]acetamide
Canonical SMILES
C(CN)COCCOCCOCCCNC(=O)CN
InChI
InChI=1S/C12H27N3O4/c13-3-1-5-17-7-9-19-10-8-18-6-2-4-15-12(16)11-14/h1-11,13-14H2,(H,15,16)
InChIKey
MJIUWBANJNMPMX-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature
Storage
Store at -5°C,keep in dry and avoid sunlight.

Gly-PEG3-amine is a versatile chemical reagent widely used in bioconjugation and therapeutic development. Here are some key applications of Gly-PEG3-amine:

Drug Delivery: Gly-PEG3-amine is used to modify drug molecules and enhance their delivery to specific tissues or cells. By conjugating this molecule to therapeutic agents, it improves their solubility, stability, and bioavailability. This is particularly beneficial in the development of targeted drug delivery systems for treating cancer and other diseases.

Protein Labeling: In the field of proteomics and biochemistry, Gly-PEG3-amine is employed to label proteins with various tags for detection, purification, or immobilization. The PEG3 spacer provides sufficient flexibility, reducing steric hindrance and maintaining protein functionality. This facilitates downstream applications such as affinity purification, imaging, and diagnostic assays.

Surface Modification: Gly-PEG3-amine can be used to functionalize surfaces with amine groups, providing a reactive site for further chemical modifications. This application is crucial in developing biosensors, tissue engineering scaffolds, and medical implants. By creating a bio-compatible and functional surface, it enhances the interaction with biological molecules and cells.

Polymer Development: Gly-PEG3-amine is utilized in the synthesis of advanced polymeric materials for biomedical applications. It serves as a building block for creating polymers with controlled architecture and functionalities. These materials are used in developing hydrogels, drug delivery vehicles, and tissue engineering scaffolds, providing tailored properties for specific applications.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: DBCO-PEG3 acetic-EVCit-PAB | m-PEG12-amine | TCO-PEG2-Sulfo-NHS ester | mPEG9-amine | THP-SS-alcohol | Amino-Tri-(carboxyethoxymethyl)-methane (hydrochloride) | Maleimido-tri(ethylene glycol)-propionic acid | Boc-aminooxy-ethyl-SS-propanol | (2-pyridyldithio)-PEG4 acid | 4-Methyl-4-(methyldisulfanyl)pentanoic acid | Gly-PEG3-amine
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