Name: Fmoc-Asn-Pro-Val-PABC-PNP
Brand: BOC Sciences
Rating: 5 (1 reviews)

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IUPAC Name

[4-[[(2S)-2-[[(2S)-1-[(2S)-4-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate

Canonical SMILES

CC(C)C(C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)C3CCCN3C(=O)C(CC(=O)N)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46

InChI

InChI=1S/C43H44N6O11/c1-25(2)38(40(52)45-27-15-13-26(14-16-27)23-59-43(55)60-29-19-17-28(18-20-29)49(56)57)47-39(51)36-12-7-21-48(36)41(53)35(22-37(44)50)46-42(54)58-24-34-32-10-5-3-8-30(32)31-9-4-6-11-33(31)34/h3-6,8-11,13-20,25,34-36,38H,7,12,21-24H2,1-2H3,(H2,44,50)(H,45,52)(H,46,54)(H,47,51)/t35-,36-,38-/m0/s1

InChIKey

DPLPVEZINJBMHS-LYDQXETESA-N

Fmoc-Asn-Pro-Val-PABC-PNP, a synthetic peptide employed in research and drug development, finds diverse applications across different domains. Here are four key applications of Fmoc-Asn-Pro-Val-PABC-PNP:

Drug Delivery Systems: Serving as a pivotal component in prodrug design, Fmoc-Asn-Pro-Val-PABC-PNP functions as a strategic linker that undergoes targeted enzymatic cleavage to unleash the active drug. This sophisticated drug delivery mechanism not only amplifies therapeutic efficacy but also mitigates adverse effects. Such systems exhibit exceptional utility in channeling chemotherapeutic agents directly to malignant cells, fostering precision medicine in the oncological arena.

Bioconjugation: Operating at the intersection of biotechnology and pharmacology, this peptide assumes a crucial role in bioconjugation strategies, acting as a versatile connector to fuse diverse biomolecules, such as antibodies or peptides, with therapeutic agents. This synergy engenders the development of innovative drug conjugates endowed with augmented selectivity and potency. Tailorable bioconjugates pave the way for personalized therapies, diagnostic advancements, and therapeutic monitoring strategies, propelling the paradigm of precision medicine forward.

Biochemical Assays: Enabling intricate studies on enzyme dynamics and substrate interactions, Fmoc-Asn-Pro-Val-PABC-PNP serves as a dynamic substrate in biochemical assays, liberating quantifiable products upon enzymatic cleavage. This feature empowers researchers to meticulously gauge enzyme activity under varied conditions, fostering insights into enzyme kinetics, inhibitor screening protocols, and mechanistic explorations.

Peptide Synthesis: Anchoring the realm of peptide synthesis, Fmoc-Asn-Pro-Val-PABC-PNP emerges as a foundational element for crafting complex peptides and proteins. Its inclusion expedites the generation of tailored peptides for diverse applications, spanning research, therapeutics, and industrial sectors. This advancement propels the frontiers of peptide-based therapies, unraveling the intricacies of protein structure and function, and spearheading innovations in healthcare and biotechnology realms.