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CAS No.: 92921-26-1
Cat No.: BADC-01193
Purity: >98.0%
4.5 
Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent which contains N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing covalent conjugation of amine- and sulfhydryl-containing molecules.
Structure of 92921-26-1
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Popular Publications Citing BOC Sciences Products
Sulfo-SMPB sodium is a water-soluble ADC linker reagent widely used in the construction of antibody-drug conjugates (ADCs) and targeted bioconjugation applications. As an effective ADC linker, Sulfo-SMPB sodium facilitates stable and site-specific conjugation between monoclonal antibodies and ADC cytotoxins, enabling precise delivery of therapeutic payloads to tumor cells. Its chemical structure incorporates a maleimide group and a sulfonate moiety, allowing efficient reaction with thiol-containing antibodies and ensuring aqueous solubility for improved handling. In ADC linker design, Sulfo-SMPB sodium supports modular conjugation strategies, maintaining antibody functionality while optimizing intracellular payload release and pharmacokinetic profiles.
Sulfo-SMPB sodium demonstrates broad compatibility with a variety of ADC cytotoxins, including microtubule inhibitors, DNA-targeting agents, and other potent payloads. Its maleimide group enables selective thiol-targeted conjugation, providing site-specific and reproducible linker attachment. This chemical feature allows precise control over ADC payload stoichiometry and conjugation efficiency, which is essential in both preclinical research and industrial-scale ADC production. The water-soluble nature of the linker reagent improves reaction efficiency and reduces aggregation risks, making it highly suitable for constructing homogeneous ADC payload conjugates with optimized therapeutic performance.
In practical applications, Sulfo-SMPB sodium is extensively employed in oncology-focused ADC research, protein modification studies, and advanced targeted drug delivery systems. Its chemical versatility allows researchers to design cleavable or non-cleavable ADC linkers tailored to specific therapeutic goals. By leveraging the predictable thiol-reactivity of Sulfo-SMPB sodium, developers can achieve high tumor specificity, efficient intracellular payload release, and minimized off-target effects. The linker’s compatibility with diverse ADC cytotoxins and robust conjugation properties make it a critical tool in the development of next-generation antibody-drug conjugates for targeted cancer therapy and bioconjugation applications.
What is Sulfo-SMPB sodium and its application in ADC linker chemistry?
Sulfo-SMPB sodium is a water-soluble heterobifunctional linker containing an NHS ester and a maleimide group. It allows selective conjugation of amine-containing antibodies to thiol-containing payloads, forming stable thioether bonds for ADC construction.
25/12/2022
We are interested in how Sulfo-SMPB sodium enables stable antibody-payload conjugation.
The NHS ester reacts with primary amines on antibodies, while the maleimide group reacts with thiols on payloads. This dual reactivity ensures stable thioether bond formation, improving ADC stability and circulation half-life.
10/8/2018
Could you inform us which payloads are compatible with Sulfo-SMPB sodium?
It is suitable for thiol-containing cytotoxins, peptides, and proteins. The water-soluble sulfo group enhances solubility, while the spacer ensures reduced steric hindrance and preservation of antibody and payload activity.
3/2/2022
Dear BOC Sciences, what are the recommended conjugation conditions for Sulfo-SMPB sodium?
Conjugation is performed in slightly basic aqueous buffers (pH 7–8.5) at controlled temperatures. This ensures selective NHS-amine and maleimide-thiol reactions while maintaining antibody and payload structural integrity.
21/11/2019
Dear team, what supporting documentation is provided for Sulfo-SMPB sodium to confirm its identity and quality?
Sulfo-SMPB sodium is supplied with a Certificate of Analysis, NMR spectra, and mass spectrometry data. These documents confirm molecular identity and structural integrity, enabling researchers to verify quality and reproducibility in conjugation reactions. Full documentation is available upon request.
9/8/2021
— Dr. Michael Scott, Senior Chemist (USA)
Sulfo-SMPB sodium demonstrated excellent thiol reactivity and solubility, critical for our ADC linker conjugations.
3/2/2022
— Ms. Emily Fischer, Biochemist (Germany)
Batch-to-batch consistency was outstanding, enabling reproducible experiments.
9/8/2021
— Dr. Thomas White, ADC Scientist (UK)
We achieved high conjugation efficiency with minimal side products using Sulfo-SMPB sodium.
21/11/2019
— Dr. Isabelle Laurent, Medicinal Chemist (France)
The reagent integrated smoothly into multi-step linker syntheses.
25/12/2022
— Dr. Helena Meyer, Research Scientist (Germany)
Sulfo-SMPB sodium allowed us to test novel linker designs, enhancing ADC diversity.
— Dr. Daniel Smith, Biochemist (USA)
Sulfo-SMPB sodium from BOC Sciences offered excellent reactivity in cross-linking applications. Documentation and shipment timing were flawless.
10/8/2018
Sulfo-SMPB sodium
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Sulfo-SMPB sodium
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