Inquiry Basket
DBCO-PEG4-vc-PAB-Duocarmycin DM is a drug-linker conjugate for ADC by using Duocarmycin DM (a potent antitumor antibiotic), linked via DBCO-PEG4-vc-PAB.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00760 | -- | $-- | Inquiry |
DBCO-PEG4-vc-PAB-Duocarmycin DM, a potent cytotoxic agent crucial for antibody-drug conjugate (ADC) development and targeted cancer therapies, showcases a myriad of applications. Here are four key applications:
Targeted Cancer Therapy: Positioned at the vanguard of cancer treatment innovation, DBCO-PEG4-vc-PAB-Duocarmycin DM assumes a pivotal role in ADC development, orchestrating the precise delivery of cytotoxic drugs exclusively to cancerous cells. The DBCO moiety facilitates seamless conjugation with antibodies, ensuring the tumor-targeted dispatch of Duocarmycin. This strategic approach not only minimizes collateral damage to healthy tissues but also diminishes systemic toxicity, thereby amplifying the efficacy of cancer therapeutics.
Cancer Research: Venturing into the realm of cancer research, scientists wield DBCO-PEG4-vc-PAB-Duocarmycin DM to scrutinize the effectiveness and mechanisms of novel ADCs in preclinical models. By evaluating the compound’s impact on cancer cell viability and proliferation, valuable insights into its potential clinical utility are gleaned.
Bioconjugation Studies: The versatile DBCO core within DBCO-PEG4-vc-PAB-Duocarmycin DM emerges as a linchpin in bioconjugation endeavors, offering a tailored approach for linking with azide-functionalized molecules via copper-free click chemistry. This unique capability streamlines the conjugation process, laying the groundwork for an array of bioconjugates tailored for both research and therapeutic applications.
Protein Modification: Charting new territories in protein modification, DBCO-PEG4-vc-PAB-Duocarmycin DM emerges as a key player in sculpting proteins and peptides for targeted delivery or imaging tasks. The PEG4 spacer enhances solubility and mitigates steric hindrance, optimizing binding to target molecules. This innovative application marks a pivotal milestone in crafting cutting-edge biomolecular tools for diagnostic and therapeutic purposes, underscoring the versatility and potential of this potent cytotoxic agent in advancing precision medicine.
Customer Support
Providing excellent 24/7 customer service and support
Project Management
Offering 100% high-quality services at all stages
Quality Assurance
Ensuring the quality and reliability of products or services
Global Delivery
Ensuring timely delivery of products worldwide
BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
