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DBCO-PEG4-VC-PAB-DMEA-((S)-Seco-Duocarmycin SA) is a click-reactive drug-linker conjugate used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01422 | -- | $-- | Inquiry |
DBCO-PEG4-VC-PAB-DMEA-((S)-Seco-Duocarmycin SA) is a complex molecule used in targeted drug delivery and cancer therapy. Here are some key applications of DBCO-PEG4-VC-PAB-DMEA-((S)-Seco-Duocarmycin SA):
Antibody-Drug Conjugates (ADCs): This compound is utilized in the design of ADCs, which are engineered to target and destroy cancer cells specifically. The DBCO group enables site-specific conjugation to antibodies, ensuring precise delivery of the cytotoxic payload. By selectively targeting cancer cells, ADCs minimize off-target effects and improve the therapeutic index.
Cellular Imaging: DBCO-PEG4-VC-PAB-DMEA-((S)-Seco-Duocarmycin SA) can be used in cellular imaging applications to study cell surface proteins and internalization mechanisms. The DBCO moiety reacts with azide-modified biomolecules in a bioorthogonal fashion, allowing for the visualization of molecular interactions. This helps researchers to track the localization and fate of the compound within living cells.
Drug Delivery Systems: This molecule is fundamental in developing advanced drug delivery systems such as polymeric nanoparticles and liposomes. The PEG4 spacer improves solubility and biocompatibility, while the cleavable VC-PAB linker ensures the controlled release of the active drug within the target cells. This enhances the efficacy and safety profile of nanoparticle-based therapeutics.
Cancer Therapeutics Research: DBCO-PEG4-VC-PAB-DMEA-((S)-Seco-Duocarmycin SA) is widely used in preclinical research to explore new cancer therapeutic strategies. By studying the pharmacodynamics and pharmacokinetics of this compound, researchers can optimize its design for better targeting and reduced toxicity. This accelerates the development of next-generation cancer therapies.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
