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DBCO-PEG3-TCO

  CAS No.:   Cat No.: BADC-01246   Purity: 98.0% 4.5  

DBCO-PEG3-TCO is a dual-functional ADC linker combining DBCO and trans-cyclooctene for SPAAC and IEDDA click chemistry, enabling fast, selective bioconjugation in antibody-drug conjugate synthesis.

DBCO-PEG3-TCO

Structure of

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Category
ADC Linker
Molecular Formula
C36H45N3O7
Molecular Weight
631.76
Shipping
Room temperature, or blue ice upon request.
Shipping
Store at -20 °C, keep in dry and avoid sunlight.

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
IUPAC Name
Canonical SMILES
C1CC=CCCC(C1)OC(=O)NCCOCCOCCOCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42
InChI
InChI=1S/C36H45N3O7/c40-34(18-19-35(41)39-28-31-12-7-6-10-29(31)16-17-30-11-8-9-15-33(30)39)37-20-22-43-24-26-45-27-25-44-23-21-38-36(42)46-32-13-4-2-1-3-5-14-32/h1-2,6-12,15,32H,3-5,13-14,18-28H2,(H,37,40)(H,38,42)/b2-1+/t32-/m1/s1
InChIKey
OYEIJQBQBCHZLD-XIASJIJZSA-N
Solubility
10 mm in DMSO
Appearance
Light yellow oil
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.

DBCO-PEG3-TCO, a versatile bioconjugation reagent, offers functionalities tailored for efficient click chemistry applications. Here are four key applications of DBCO-PEG3-TCO:

Bioorthogonal Chemistry: Playing a pivotal role in bioorthogonal reactions, DBCO-PEG3-TCO enables the precise modification of biomolecules at specific sites, all while maintaining the integrity of natural cellular processes. Researchers utilize this reagent to tag proteins, nucleic acids, and other biomolecules in a remarkably specific manner. This technique proves invaluable for dissecting dynamic biological processes within live cells and organisms.

Therapeutic Development: In the realm of drug delivery and therapeutic advancement, DBCO-PEG3-TCO emerges as a key player. It facilitates the conjugation of therapeutic agents with targeted ligands or antibodies, ensuring the precise delivery of drugs to designated cells or tissues. Such targeted delivery not only enhances therapeutic effectiveness but also mitigates off-target effects and toxicity.

Diagnostics: DBCO-PEG3-TCO finds application in diagnostic imaging and assay development, revolutionizing the visualization and detection of specific cellular components or disease markers. By attaching imaging agents or probes to biomolecules of interest, this reagent aids in accurate diagnosis and monitoring of disease progression. Its role in diagnostic precision is paramount for improving patient outcomes and treatment strategies.

Biomolecular Engineering: Powering biomolecular innovation across research and industry, DBCO-PEG3-TCO enables the precise conjugation of functional groups, leading to the creation of novel biomaterials and enzymes with enhanced properties.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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