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CAS No.: 1807521-07-8
Cat No.: BADC-00401
Purity: ≥98%
4.5 
Ald-Ph-PEG2-NHS is a PEG-based spacer and synthetic linker building block used to introduce a defined hydrophilic and flexible segment into multistep conjugation designs. The PEG chain can increase molecular spacing and provide a modular connection between reactive groups without serving as a dedicated cleavage trigger. This derivative contains peg2 spacer together with terminal functionality selected for further synthesis. The available reactive group is no dedicated antibody-reactive group unless activated/functionalized; terminal functionality depends on the specific peg derivative. The opposite terminus provides terminal peg functionality depends on the specific derivative; additional activation may be required. Coupling and deprotection conditions should be matched to the terminal groups and the intended order of assembly.
Structure of 1807521-07-8
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Ald-Ph-PEG2-NHS, a versatile bioconjugation reagent, finds its footing in a diverse spectrum of biomedical and biochemical pursuits. Here are four key applications elaborated with a high level of perplexity and burstiness:
Protein Labeling: A foundational tool in the biologist's arsenal, Ald-Ph-PEG2-NHS assumes a crucial role in the precise labeling of proteins at specific sites. By interacting with primary amines housed within lysine residues, this reagent facilitates the bonding of fluorescent dyes or other molecular reporters. This synergistic alliance allows for exploration into protein localization, interactions, and dynamics through the intricate lens of fluorescence microscopy and other visualization techniques.
Antibody-Drug Conjugates (ADCs): Leading the charge in anticancer breakthroughs, Ald-Ph-PEG2-NHS contributes its expertise to the fusion of cytotoxic drugs with antibodies. This collaboration forges unwavering covalent bonds that orchestrate the targeted delivery of therapeutic payloads to cancerous cells while mitigating collateral damage. Such pinpoint accuracy enhances the efficacy and safety profile of cancer treatments, heralding a new epoch in oncological therapy.
Surface Functionalization: Within the realms of nanotechnology and biomaterials, Ald-Ph-PEG2-NHS plays a pivotal role in customizing surface functionalities. By grafting functional groups onto nanoparticles, beads, or similar materials, it ushers in a realm of opportunities for biomedical applications. This transformation opens doors for attaching biologically active molecules like peptides, antibodies, or ligands, crucial for biosensing, precise drug delivery, and diagnostic assays with finesse and accuracy.
Protein Stabilization: Leading the forefront in protein preservation, Ald-Ph-PEG2-NHS serves as a beacon in enhancing the stability and solubility of proteins. Through the art of pegylation, it shields against aggregation, proteolysis, and immunogenic threats, thereby extending the protein's longevity and bioavailability. This reinforcement proves invaluable in the development of therapeutic interventions and biopharmaceuticals across an array of diseases, embodying the pinnacle of protein preservation science.
Ald-Ph-PEG2-NHS
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Ald-Ph-PEG2-NHS
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