Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-00004 | Colchicine | 64-86-8 |
| Colchicine, a toxic plant-derived alkaloid extracted from plants of the genus Colchicum, inhibits microtubule polymerization (IC50 = 3.2 μM). It inhibits the growth of MCF-7 human breast carcinoma cells and has anti-inflammatory activity. Colchicine can lower body temperature, inhibit the respiratory center, enhance the effect of sympathomimetic drugs, constrict blood vessels, and raise blood pressure. | Inquiry | |
| BADC-00008 | Val-Cit-PAB-MMAE | 644981-35-1 |
| Val-Cit-PAB-MMAE, a tubulin polymerase inhibitor, is a drug-linker conjugate for ADC. It contains an ADC linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE. | Inquiry | |
| BADC-00009 | DM1-SMCC | 1228105-51-8 |
| DM1 with a reactive linker SMCC, which can react with antibody to make antibody drug conjugate, as a potent EGFR inhibitor and it overcomes resistant to EGFR. | Inquiry | |
| BADC-00010 | DM1-SPP | 452072-20-7 |
| DM1 with a reactive linker SPP, which can react with antibody to make antibody drug conjugate, as a potent EGFR inhibitor and it overcomes resistant to EGFR. | Inquiry | |
| BADC-00011 | DM4-SPDP | 2245698-48-8 |
| DM4 with a reactive linker SPDP, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site. | Inquiry | |
| BADC-00012 | DM4-SPDB | 1626359-62-3 |
| DM4 with a reactive linker SPDB, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site. | Inquiry | |
| BADC-00013 | MC-Val-Cit-PAB-MMAF | 863971-17-9 |
| MC-Val-Cit-PAB-MMAF is a potent tubulin inhibitor (MMAF), Val-Cit-PAB-MMAF is an antibody drug conjugate. | Inquiry | |
| BADC-00014 | Mc-MMAF | 863971-19-1 |
| Mc-MMAF is a protective group-conjugated MMAF, MMAF is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin and it has lower cytotoxic activity than MMAE. | Inquiry | |
| BADC-00016 | Vat-Cit-PAB-MMAD | 1415329-13-3 |
| Vat-Cit-PAB-MMAD is a protective group conjugated MMAD, MMAD is a toxin payload in antibody drug conjugate. | Inquiry | |
| BADC-00020 | DM1-SMe | 138148-68-2 |
| DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). . | Inquiry | |
| BADC-00021 | DM4-SMe | 796073-68-2 |
| DM4-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). . | Inquiry | |
| BADC-00022 | DM3-SMe | 796073-70-6 |
| DM3-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). . | Inquiry | |
| BADC-00023 | Trastuzumab emtansine | 1018448-65-1 |
| Trastuzumab emtansine is an antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surface surfaces. Upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers. | Inquiry | |
| BADC-00025 | Mc-MMAE | 863971-24-8 |
| Mc-MMAE is a protective group conjugated MMAE, MMAE inhibits tubulin polymerization so that it inhibits cell division. | Inquiry | |
| BADC-00029 | MC-Val-Cit-PAB-MMAE | 646502-53-6 |
| MC-Val-Cit-PAB-MMAE is a potent tubulin inhibitor (MMAE), Val-Cit-PAB-MMAE is an antibody drug conjugate. | Inquiry | |
| BADC-00033 | PNU-159682 | 202350-68-3 |
| PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes. It is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity, and shows >3,000-fold cytotoxic than its parent compound (MMDX and doxorubicin). It is a more potent and well tolerated ADC cytotoxin than doxorubicin. | Inquiry | |
| BADC-00036 | Triptolide | 38748-32-2 |
| Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It has immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is an NF-κB activation inhibitor. | Inquiry | |
| BADC-00037 | Methotrexate | 59-05-2 |
| Methotrexate(WR19039; CL14377) can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. | Inquiry | |
| BADC-00038 | Doxorubicin hydrochloride | 25316-40-9 |
| Doxorubicin is an anthracycline antibiotic with antineoplastic activity produced by the bacterium Streptomyces peucetius var. Doxorubicin is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. | Inquiry | |
| BADC-00040 | Dolastatin 10 | 110417-88-4 |
| Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibiting microtubule assembly. | Inquiry |
