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ADC linker is the bridge between antibodies and cytotoxic drugs and plays a key role in antibody-drug conjugate (ADC) drugs because its properties greatly affect the therapeutic indicators, efficacy, and pharmacokinetics of these drugs. The ideal conjugation must be stable in vitro or in the blood circulation to prevent systemic toxicity caused by premature release of cytotoxic drugs, while at the same time being able to enter and kill cancer cells through the rapid release of effective cytotoxic drugs. BOC Sciences can provide ADC linkers with multiple cleavage mechanisms according to your project needs, including enzymatic cleavage linkers, chemical cleavage linkers and peptide linkers. We also support the integrated design of linkers to modulate payload release and ADC stability for optimal efficacy of ADC drugs.
