Name: Fmoc-3VVD-OH
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-methoxy-4,10-dimethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(2R,3S,4S)-1-carboxy-2-methoxy-4-methyl-3-hexanyl]-N-methyl-L-valinamide; L-Valinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-; FMOC-3AA-OH

IUPAC Name

(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methoxy-5-methylheptanoic acid

Canonical SMILES

CCC(C)C(C(CC(=O)O)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

InChI

InChI=1S/C36H51N3O7/c1-10-23(6)33(29(45-9)19-30(40)41)38(7)35(43)31(21(2)3)37-34(42)32(22(4)5)39(8)36(44)46-20-28-26-17-13-11-15-24(26)25-16-12-14-18-27(25)28/h11-18,21-23,28-29,31-33H,10,19-20H2,1-9H3,(H,37,42)(H,40,41)/t23-,29+,31-,32-,33-/m0/s1

InChIKey

SMVBIYSFDNRJJI-FCUBIXSHSA-N

Density

1.1±0.1 g/cm3

Solubility

Soluble in DMSO

Shipping

Room temperature

Storage

Store at 2-8°C, stored under nitrogen

Boiling Point

793.0±60.0°C at 760 mmHg

Fmoc-3VVD-OH, a fluorenylmethyloxycarbonyl (Fmoc) protected amino acid derivative, plays a pivotal role in peptide synthesis and biochemical research. Here are four key applications of Fmoc-3VVD-OH:

Peptide Synthesis: Essential in solid-phase peptide synthesis (SPPS), Fmoc-3VVD-OH facilitates the precise assembly of intricate peptide chains. The Fmoc group shields the amino terminal, safeguarding against undesirable reactions during synthesis. This meticulous process ensures the synthesis of peptides with pristine purity and accuracy, critical for a myriad of biochemical and pharmaceutical investigations.

Drug Development: Leveraging Fmoc-3VVD-OH within peptide libraries is instrumental in the exploration of novel therapeutic peptides possessing drug-like attributes. Researchers can design and evaluate diverse peptide sequences to screen for biological activity, binding affinity, and stability. This methodology expedites the identification and refinement of peptide-based drugs aimed at combating various diseases,.

Protein Engineering: In the realm of protein engineering, Fmoc-3VVD-OH is deployed to craft modified peptides and proteins endowed with distinctive properties and functions. By integrating this specific amino acid derivative into protein sequences, researchers introduce a spectrum of structural and functional diversity. These tailored proteins serve as invaluable tools for probing protein interactions, stability, and functionality across diverse biological contexts, enriching our understanding of protein behavior.

Bioconjugation: Fmoc-3VVD-OH plays a pivotal role in the development of peptide conjugates that link peptides to other molecules like drugs, probes, or nanoparticles. This conjugation enhances the specificity, delivery, and efficacy of therapeutic agents and diagnostic tools. Bioconjugates formulated with Fmoc-3VVD-OH find application in targeted drug delivery, imaging techniques, and biosensor technologies.