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| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01241 | -- | $-- | Inquiry |
DBCO-(PEG2-Val-Cit-PAB)2, a specialized chemical linker, plays a pivotal role in bioconjugation and drug delivery systems, particularly in the advancement of antibody-drug conjugates (ADCs). Here are four key applications of DBCO-(PEG2-Val-Cit-PAB)2:
Antibody-Drug Conjugates (ADCs): Positioned at the forefront of cancer therapy, this compound is indispensable for constructing ADCs that link potent cytotoxic drugs to specific antibodies targeting cancer cells. The PEG2 spacer adds bioavailability and flexibility, while the Val-Cit dipeptide responds to tumor-associated proteases to ensure drug release at the precise site. This meticulous delivery strategy heightens therapeutic efficacy and minimizes unintended impacts with surgical precision.
Bioconjugation: A cornerstone of bioconjugation endeavors, DBCO-(PEG2-Val-Cit-PAB)2 excels at labeling biomolecules such as proteins, peptides, and nucleic acids. The DBCO group interacts with azide-containing molecules through strain-promoted azide-alkyne cycloaddition (SPAAC), enabling efficient and enduring conjugation. This capability is crucial for crafting versatile bioconjugates utilized in diagnostics, imaging, and therapeutics across a diverse array of applications, pushing the boundaries of biotechnology.
Targeted Drug Delivery: Serving as a linchpin in the evolution of targeted drug delivery systems, this linker ensures the controlled release of therapeutic agents in response to specific triggers found in the tumor microenvironment. The PEG2-Val-Cit component guarantees stability during circulation and triggers drug release following enzymatic cleavage. Such precision drastically reduces systemic toxicity and amplifies the therapeutic potential of anticancer treatments.
Pharmaceutical Research: Within the intricate landscape of drug discovery and development, DBCO-(PEG2-Val-Cit-PAB)2 assumes a pivotal role in formulating dual-targeted or multifunctional drugs. Researchers leverage its capabilities to fuse disparate bioactive molecules, amalgamating therapeutic and diagnostic functionalities seamlessly. This adaptability cultivates the creation of cutting-edge therapies capable of diagnosing and treating diseases simultaneously, particularly within the dynamic realm of oncology.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
