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| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01242 | -- | $-- | Inquiry |
DBCO-NHCO-S-S-NHS ester is a bifunctional crosslinker used primarily in bioconjugation applications. Here are some key applications of DBCO-NHCO-S-S-NHS ester:
Site-Specific Labeling: DBCO-NHCO-S-S-NHS ester is employed to achieve site-specific labeling of biomolecules such as proteins without disrupting their native functions. Its activated NHS ester reacts with primary amines, while the DBCO group is used for strain-promoted azide-alkyne cycloaddition (SPAAC) reactions. This ensures a highly specific and efficient labeling process, essential for studying protein interactions and localizations.
Drug Delivery Systems: This crosslinker is used in creating novel drug delivery systems where precise conjugation of drugs to specific carriers is critical. By linking therapeutic agents to targeting molecules, it helps in enhancing the specificity and efficacy of drug delivery. This improves the therapeutic index and reduces off-target effects, benefiting the treatment of diseases such as cancer.
Antibody-Drug Conjugates (ADCs): DBCO-NHCO-S-S-NHS ester is utilized in the development of antibody-drug conjugates, which are targeted cancer therapies. The NHS ester functionality attaches to the antibody, while the DBCO group facilitates attachment to drug payloads via click chemistry. This results in a stable and precise linkage, significantly improving the therapeutic potential of ADCs.
Biomaterials Functionalization: The compound is used to functionalize biomaterials such as hydrogels and nanoparticles for various biomedical applications. By modifying these materials with specific biological ligands or peptides, researchers can tailor their properties for controlled cell interactions and tissue engineering. This customization leads to more effective biomaterials for regenerative medicine and medical device applications.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
