Name: DBCO-NHCO-PEG4-NH-Boc
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

tert-butyl N-[2-[2-[2-[2-[3-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate; DBCO-NH-PEG4-NH-Boc; tert-butyl N-{14-[(3-{2-azatricyclo[10.4.0.0,hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-3-oxopropyl)carbamoyl]-3,6,9,12-tetraoxatetradecan-1-yl}carbamate

IUPAC Name

Canonical SMILES

CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)NCCC(=O)N1CC2=CC=CC=C2C#CC3=CC=CC=C31

InChI

InChI=1S/C34H45N3O8/c1-34(2,3)45-33(40)36-17-19-42-21-23-44-25-24-43-22-20-41-18-15-31(38)35-16-14-32(39)37-26-29-10-5-4-8-27(29)12-13-28-9-6-7-11-30(28)37/h4-11H,14-26H2,1-3H3,(H,35,38)(H,36,40)

InChIKey

YUOUOEOEOWCRQI-UHFFFAOYSA-N

Solubility

DMSO, DCM, DMF

Shelf Life

-20°C 3 years powder; -80°C 2 years in solvent

Shipping

Room temperature

Storage

-20°C

DBCO-NHCO-PEG4-NH-Boc, a versatile bifunctional reagent utilized in bioconjugation and click chemistry applications, exhibits a wide array of uses. Explore these four key applications:

Protein Labeling: Through the innovative copper-free click chemistry approach, researchers leverage DBCO-NHCO-PEG4-NH-Boc for precise protein labeling with diverse tags or fluorophores. This advanced reagent enables efficient and specific conjugation under mild conditions, preserving protein functionality. Scientists employ this method to delve into protein interactions and dynamics within living cells.

Drug Delivery Systems: In the domain of drug delivery research, DBCO-NHCO-PEG4-NH-Boc serves as a vital tool for linking therapeutic agents to targeted moieties like antibodies or peptides. This conjugation strategy enhances the specificity of drug delivery to intended cells or tissues, minimizing side effects and maximizing therapeutic effectiveness. The inclusion of the flexible PEG4 linker mitigates potential steric hindrance, optimizing drug delivery precision.

Biomaterial Functionalization: Embracing biomaterial innovation, DBCO-NHCO-PEG4-NH-Boc empowers the functionalization of biomaterials such as hydrogels or nanoparticles with bioactive compounds. This process facilitates the creation of advanced materials tailored for specific properties crucial in tissue engineering or diagnostic applications. The utilization of this reagent enables precise and stable modifications, essential for crafting responsive biomaterials that push the boundaries of material science.

Diagnostic Assays: In the realm of diagnostic assay development, DBCO-NHCO-PEG4-NH-Boc plays a pivotal role in attaching detection probes to antibodies or other binding molecules. This modification enables the sensitive and specific detection of target analytes across various sample matrices. The integration of click chemistry expedites the conjugation process, enhancing assay performance and reliability.